Neural Cell Specification: Molecular Mechanisms and Neurotherapeutic ImplicationsBernhard H.J. Juurlink, Patrick H. Krone, William M. Kulyk, Valerie M.K. Verge, J. Ronald Doucette Springer Science & Business Media, 6. des. 2012 - 310 sider The last decades have witnessed a radical change in our views on central nervous system damage and repair. This change is not only due to the emergence of new powerful tools for the analysis of the brain and its reactions to insults, but it also reflects a conceptual change in the way we approach these problems. As an illustration to this development, it is instructive to go back to the proceedings of a meeting at the NIH in 1955 edited by William F. Windle, which summarizes the disillusioned and pessimistic view on CNS regeneration prevailing at the time. While this generation of researchers were well aware of the issues at stake, they felt they had reached the end of the road; the approaches they had pursued had got stuck and the tools available could not take them any further. I can very well imagine that the participants, most of them leaders in the field, left that conference feeling they had heard their field being sentenced to death. |
Innhold
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Genetic Mechanisms Responsible for Pattern Formation in the Vertebrate | 17 |
Pax Genes as Pleiotropic Regulators of Embryonic Development | 29 |
Induction and the Generation of Regional and Cellular Diversity | 51 |
Potential Role of Homeobox Genes in Neural Cell Differentiation | 69 |
Antibody against myelinassociated inhibitor of neurite | 85 |
Multiple Roles for Proneural Genes in Drosophila Neurogenesis | 97 |
Genetic Analysis of Neuronal Migration in the Nematode | 105 |
Targeted Neocortical Cell Death Guides the Fate of Transplanted Neural | 195 |
Transplanted neural tissue develops connections with | 197 |
Neurodegeneration Induced by Deregulation of Neurofilament Gene | 209 |
Preliminary Results | 219 |
Using Fetal Mesencephalic Grafts to Treat MPTPInduced Parkinsonism | 231 |
Brain grafts | 239 |
Incorporation of Cells into Adult Fibre Tracts | 241 |
Characteristics of Intraspinal Grafts and Locomotor Function after | 249 |
Induction and Differentiation of Motor Neurons | 111 |
Neuronal Development in the Rat Sympathoadrenal Lineage | 127 |
Specification of Cell Fate in the Vertebrate Retina | 139 |
From Precursor Cell Biology to Tissue Repair in the O2A Lineage | 171 |
Neuronal Cell Specification from CNS Stem Cells | 185 |
Role of TargetDerived Neurotrophins in the Maintenance of Developing | 267 |
Axons from CNS neurones | 284 |
Modulation of Cell Death in Neural Cell Lines and Transplants | 285 |
Contributors | 301 |
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Neural Cell Specification: Molecular Mechanisms and Neurotherapeutic ... Bernhard H.J. Juurlink,Patrick H. Krone,William M. Kulyk,Valerie M.K. Verge,J. Ronald Doucette Ingen forhåndsvisning tilgjengelig - 2012 |
Neural Cell Specification Bernhard H J Juurlink,Patrick H Krone,William M Kulyk Ingen forhåndsvisning tilgjengelig - 1995 |
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