The Clinical Evaluation of a Food Additive: Assessment of AspartameChristian Tschanz, Harriett H. Butchko, W. Wayne Stargel, Frank N. Kotsonis CRC Press, 25. juni 1996 - 320 sider This useful book reviews and analyzes the rigorous scientific, regulatory, and clinical testing and evaluation applied to the widely used food additive aspartame. In one compact volume you gain access to extensive information illustrating the increased recognition by regulatory agencies of the usefulness of human studies in evaluating new food additives. The Clinical Evaluation of a Food Additive: Assessment of Aspartame begins by describing the nuts and bolts of food additive safety evaluation in humans, including an insightful historical perspective of the development of good clinical practice guidelines. It provides the regulatory requirements for human research, as well as key elements for the design and conduct of human studies. The scientific and regulatory considerations of food additive safety are explored, including interesting descriptions of aspartame's key animal safety studies. In addition, the book reviews the medical postmarketing surveillance system developed for identifying and evaluating reports of aspartame's alleged adverse health effects. Through meticulous research and systematic clarity, The Clinical Evaluation of a Food Additive: Assessment of Aspartame provides work-saving, state-of-the-art examples to guide future testing and evaluation of tomorrow's food additives. |
Innhold
Scientific and Regulatory Considerations | 23 |
Chapter 4 | 43 |
Chapter 5 | 57 |
Concentrations in Potentially Sensitive Populations | 87 |
Safety Evaluation in Pregnancy | 115 |
Chapter 10 | 137 |
Chapter 11 | 149 |
Chapter 13 | 169 |
Chapter 14 | 183 |
Chapter 16 | 205 |
Chapter 18 | 223 |
Chapter 19 | 255 |
Chapter 21 | 275 |
Chapter 22 | 289 |
Vanlige uttrykk og setninger
absence seizures adverse experiences animals aspartame and placebo aspartame consumption aspartame ingestion aspartame intake aspartame-sweetened beverage aspartic acid baseline behavior biochemical carbohydrate chronic Clin clinical studies cognitive concentrations in normal consumed diabetes diet disease doses of aspartame double-blind Drug Administration effects of aspartame evaluated food additive Food and Drug food intake G. D. Searle glucose headache hepatic encephalopathy heterozygous human increased individuals insulin Kotsonis large neutral amino levels liver LNAA meal mean plasma phenylalanine metabolism methanol mg of aspartame mg/kg body weight mg/kg/day neurotransmitter neutral amino acids normal adults Nutr obese patients Phe/LNAA phenylketonuria PKU heterozygotes placebo plasma amino acid plasma concentrations plasma phenylalanine concentrations postmarketing surveillance postprandial potential protein rats reactions renal reported safety seizures statistically significant Stegink submitted by G. D. sucrose sugar sweeteners symptoms Teratogenic teratology toxicity Toxicol Toxicology treatment tryptophan tyrosine urine Wurtman
Referanser til denne boken
Nutritional Toxicology, Second Edition Frank N. Kotsonis,Maureen A. Mackey Ingen forhåndsvisning tilgjengelig - 2001 |