ciently sterilized. The paper also makes suggestions as to dental hygiene. A wide demand for this bulletin among dentists has been shown. 5. The fifth article describes a modification of Rose's method for estimation of pepsin. 102 1. Digitalis Standardization. The Physiological Evaluation of Fat Free Dates and Commercial Ing talis By George Roth 2. Preliminary Observations of Metabolism in Pellagra. By Andrew Hunter, Maurice H Givens, and Robert C. Lewis, 1. The necessity for satisfactory standardization of digitalis preparations has long been recognized, and with the object of devising a satisfactory standard, an extensive series of investigations has been carried on in the division of pharmacology. The results are contained in the first paper of this bulletin. 2. The second article gives the results of certain observations of metabolism in pellagra, which constitute valuable additions to the bulk of evidence on the subject from which one day statistical conclusions can be derived. 1031 Chemical Changes in the Central Nervous System as a Result of ReStricted Vegetable Diet. By Mathode 1. Koch and Cari Voegtan 2. Chemical Changes in the Central Nervous System in Pellagra. Hy Malade L. Koch and Carl Voegtiin The two papers in this bulletin compare the chemical changes in the nervous system resulting from restricted vegetable diets, with those observed in pellagra. Certain points of close resemblance are demonstrable by chemical examination. In pellagra the changes are most marked in the spinal cord and principally involve certain Ipords. 104 Investigation of the Pollution and Sanitary Conditions of the Potomac Watershed. With special reference to sef Purification and the Nanitary Condition of Shellfish in the Lower Potomac By High S Cuntaing; Pirkton Studies by WC Pardy and Hydrographie Stades by Hotu↑ P Rater This bulletin records the results of one of a series of investigations made and contemplated by the Service, the chief object of which is to determine the sanitary features of various interstate streams of different types both physically and in relation to the population and human activities on their basins. When general facts applying to streams of a given type have been determined, the work of ascertaining the sanitary condition of other streams of the same type is much ful tited The Potomac River really represents two very different types of stream; the one relatively rapidly flowing, traversing mountino is sparsely popolated cour try, with nevertheless a consideral le amor of manufacturing activity along its banks; in 1 the other, represet to i Ey the lower portion, es entially a tidal estuary, having a large city with heavy crude sew ige poliation at its head, and supporting Largeste tchat distry in the lower salie reaches De ballet in record a war-tary survey of the upper watershed an I the effects of the sew agy ar dard strial poll tion, on the condition of the water it Vartonin sest ots. The most interest rg feature of U'e lower river is the degree an i manner of purification accomplished 'y natural age 15 to st. 1 fro motion of the tales has the effist of greatly lengthening the time during which a given particle of water is subjected to the agencies inimical to pollution, so that before the shellfish bearing area is reached, the water has been restored to a good sanitary condition. The very few instances of pollution of oyster beds are traced to local conditions. Incidentally, important contributions to the bacteriology and chemistry of water, to the methods of securing samples, and the flora and microscopic fauna of the river, having sanitary significance, are included. The text is well illustrated with maps, charts, diagrams, etc., and pictures of aquatic forms of life. 105. Digest of Comments on the Pharmacopoeia of the United States of America and on the National Formulary. By Martin I. Wilbert. This bulletin is a continuation of previous digests of comments and brings the work up to December 31, 1914. Previous bulletins along this line have been in great demand." PUBLIC-HEALTH BULLETINS, These bulletins are less technical in character than the preceding series. In fact, many of them are popular in style and prove very useful in connection with the vigorous campaigns for rural sanitation being carried on by the service in the Southern States. However, generally speaking, and especially with regard to the compilations of State laws on various subjects, these bulletins are found extremely valuable by health officers and officials who are charged with the duty of combating epidemics of disease. They frequently learn from these documents that the problems which trouble them have already been solved by other States, and avail themselves of the example of salutary legislation by which the desired result is accomplished. An accurate idea of these documents can be best obtained by reference to the following list issued during the last fiscal year: 71. Studies in Vocational Diseases. I. The Health of Garment Workers. By J. W. Schereschewsky. II. The Hygienic Conditions of Illumination in Workshops of the Women's Garment Industry, By J. W. Schereschewsky and D. H. Tuck. This bulletin reports a comprehensive investigation of the health of workers in the cloak and suit, and dress and waist industries in New York City and of the hygienic conditions under which they work. The scope and results of this investigation were described in the last annual report, pages 46-49. 72. Transactions of the Thirteenth Annual Conference of State and Territorial Health Officers with the United States Public Health Service, Washington, May 13, 1915. The following subjects were taken up at the conference: Interstate Quarantine Regulations, morbidity reports, pollution of navigable waters, malaria, sanitation of public conveyances, transportation of tuberculous persons, rural sanitation, pellagra, sickness insurance, and leprosy. 73. Tuberculosis Among Industrial Workers. Report of an Investigation made in Cincinnati, with special reference to predisposing causes. By D. E. Robinson and J G. Wilson. 143 pages. The investigation here reported was described in the last annual report, pages 49 50. The study was not limited to the industries alone, but was extended into other fields in an attempt to determine the most important causes predisposing to the high mortality from tuberculosis. 74. Investigation of the Pollution of Tidal Waters of Maryland and Virginia, with special reference to shellfish bearing areas. By Hugh S, Cullaila. This is the second comprehensive report on the pollution of coastal waters, the first having been published as Hygiène Laboratory Bulletin No. 104. The investigation here reported was described in the annual report for 1915, pages 10% 110, 75. Studies Upon Leprosy, XXVIII XXXIII. By G. W. McCoy, H. T. Hollmann, W. J. Goodline, M. T. Clegg. The results of investigations made at the leprosy investigation station, Hawaii, are presented in these six papers They comprise articles on the chaulmoogra oil treatment of leprosy, carbon dioxide snow in the treatment of leprosy, B. Lepre in the circulating blood of lepers, leprosy in a nineteen months old child, the cultivation of a nonchromogenic acid fast bacillus from a case of nodular leprosy, and a note concerning the favorable influence of glucose on the growth of acid-fasts 70 Health Insurance. Its relation to the public health. By B. 8. Warren and Fälgar Sydenstricker, This bulletin deals with the prevalence and cost of sickness amot.g wageworkers, the conditions causing it, the responsibility for those conditions, and the need of cooperative action for relief and preven Asheme of health insurance is proposed and docussed. PUBLIC HEALTH REPORTS, These reports are issued on Friday of each week, and in accordance with law are distributed to "health officers," "collectors of customs," and "other sanitarians" It is in these weekly reports that the health otheers of the country find much of their best material for safeguard ing the health of their respective communities. The reports contain each week statistics on the prevalence of disease throughout this and foreign countries, together with sanitary legislation enacted by States and municipalities to meet these diseases and insanitary conditions and court decisions construing various laws, State and national, re lating to public health. The weekly editions during the past year reached a maximum of 15,650 copies. REPRINTS FROM THE PUBLIC HEALTH REPORTS, The reprints are "separates" of levling articles appearing es h week in the Public Health Reports. By ressit g them as separates in pamphlet form, it becomes possible to distriteite them in large quantities at comparatively small expense and thus reach a very large number of readers who do not receive the weekly Publi Health Re portThe value of these " rene nts” to the pulle will become evi dent from a reading of the following hit of titles of those issued last year The Model State Law for Morbidity Reports. As amended by the th 。 ཝཱ ཝཱ སྙལ་མམ་*® 3 2. Zooparasitic Intestinal Infections. An analysis of infections found among 1,287 school children (776 white, 511 negro) of the city of X. By C. W. Stiles. July 2, 1915. 27. The Practical Use of Disinfectants. By H. E. Hasseltine. July 2, 1915, 28 Intestinal Infections. The school grades attained by 2,166 white school children (1,062 boys, 1.104 girls) in the city of X, classified by age, sanitation, and intestinal parasites. By C. W. Stiles, July 2, 1915, 29. Post-Vaccination. Studies on its relation to vaccine virus. By John F. Anderson. July 16, 1915. 20. Anopheles as a Winter Carrier of Plasmodium. The mosquito as a prophylactic indicator. By M. Bruin Mitzmain. July 16, 1915. 291. The Notifiable Diseases. Prevalence during 1914 in cities of over 100,000. Diphtheria, gonorrhea, leprosy, malaria, measles, epidemic cerebrospinal miningitis, poliomyelitis, rabies, scarlet fever, smallpox, syphilis, tuberculosis, and typhoid fever. Cases reported, case rates per 1,000 population, and fatality rates per 100 cases. July 23, 1915. 292. Embalming. Indefinite preservation of the body. By Edward Francis. July 30, 1915. 293. Methods of Destroying Lice. Abstract of article by J. Parlane Kinloch, M. D. August 6, 1915. 24. The Number and Kind of Drug Addicts. By Martin I. Wilbert. August 6, 1915. 295. Standard for Determining the Purity of Milk. The limit of error in baeteriological milk analyses, By H. W. Conn, Wesleyan University. Middletown, Conn. August 13, 1915. 26. The Trachoma Problem. By J. W. Kerr. August 20, 1915. 7. The Pharmacy of Useful Drugs. By Martin 1. Wilbert, August 27, 1915. 28. The Notifiable Diseases. Reported prevalence during 1914 by States, Dengue, diphtheria, gonorrhea, leprosy, malaria, measles, epidemie cerebrospinal meningitis, poliomyelitis, rabies, Rocky Mountain spotted fever, scarlet fever, septic sore throat, smallpox, syphilis, tuberculosis, typhoid fever, and typhus fever. Cases reported, indicated case rates per 1,000 population and indicated fatality rates per 100 cases. September 3, 1915. 299. Essentials of Swimming-Pool Sanitation. By Wallace A. Manheimer, Ph. D. September 17, 1915. 300, Public Health Administration in Chicago, Ill. A study of the organization and administration of the city health department. By J. C. Perry, August 20 September 24, 1915, 301. Tobacco and Snuff: Their use by white school children in the city of X. By C. W. Stiles and D. N., Richards, October 1, 1915, 302. Industrial Hygiene. A plan for education in the avoidance of occupational diseases and injuries, By J. W. Schereschewsky, October 1, 1915 303. Heights and Weights of Children. Classification, by age and by sanitation, of 1,652 white school children (771 boys, 881 girls) in the city of X. By C. W. Stiles and George A. Wheeler. October 8, 1915. 304. An Efficient Liquid Disinfectant. A formula by which one can be readily prepared. By Albert F. Stevenson. October 8, 1915, 36. Cosmetics as Drugs. A review of some of the reported harmful effects of the ordinary constituents of widely used cosmetics, By Martin L. Wilbert. October 15, 1915. 3. Lung Capacity of Children. Spirometer tests of 1,618 white school children (751 boys, 867 girls) in the city of X. By C. W. Stiles and Floyd Graves October 15, 1915. 307. The Prevention of Pellagra. A test of diet among Institutional Inmates, By Joseph Goldberger, C. H. Waring, and David G. Willets. October 22. 1915. 308. The Prevalence of Pellagra. Its possible relation to the rise in the cost of food. By Edgar Sydenstricker. October 22, 1915 309. Tuberculosis: With special reference to its epidemiology transmissibility and prevention. By George M. Kober, M. D. October 29, 1915. 310. The Division of Sanitary Reports and Statistics. Bureau of the Pubile Health Service, November 5. 1915, 311. Experimental Pellagra in the Human Subject Brought About by a Restricted Diet. By Joseph Goldberger and G. A. Wheeler. November 12. 1915. PUBLIC HEALTH SERVICE. 312 The Notifiable Diseases. Prevalence during 1914 in cities of 10.000 to 314. Strychnine Sulphate. Its effect on California valley quail. By C C Pierce 315. Public Health Administration in North Dakota. By Carroll Fox ber 17 1915, 316 Memory Tests of School Children. Memory span of 1,585 white sharmal children (751 boys, 834 girls) in the city of X. By C. W. Sties December 24 1915. 317. Public Health Administration in Nevada. By Carroll Fox. December 31. 1915 31 Standards for Milk. Their necessity to the welfare of the dairy industry By John F Anderson January 7, 1914 319. The Practicing Physician. What he should know about the registration of births and deaths and the reporting of sickness. By J. W. Trask. January 14, 1915, 3) Pyorrhea Alveolaris. Preliminary report on treatment with Ipevac and emetin hydrochloride. By John S. Ruoff January 21, 1916 321 Narcotic Drugs. Recent legislation designed to restrict their use. By MI. Wubert January 21, 1916. 322 Mental Manifestations of Pellagra. By W F. Lorenz. February 4, 1916 324. Anopheles Punctipennis Say. Its relation to the transmission of malaria 325. Vitamines and Nutritional Diseases. A stable form of vitamine, eff. letit in the prevention and cure of certain nutritional deficiency diseases By Atherton Selde'l February 18, 1916 32 Community Sickness Survey. Rochester, N. Y., September, 1915. By Lee k Frankel Ph D and Louis 1. Dublin February 25 1914 327 Rocky Mountain Spotted Fever. A report of laboratory investigations of the viruum By L. D. Fricks March 3, 1916 3. Demonstrations of Malarial Control. By RH. von Endorf March 10 1916 32 Death Rates of the Colored Population. Their trend and significance in the United States By John W. Tramà La Poisons and Habit-Forming Drugs. A digest of laws and regu'stions reMarch 17, 1916 lating to the jamnamnjola 1ibit form.ng drugs et acted during 1914 nad 1915 now in force in tise male and manufacture of potsotis atst the United States February 18 to March 24 1966 By Martin | Wilbert 3:1 Endemic Index of Malaria in the United States. Hy R. H von Endorf The Notifiable Diseases. Diseines and conditions required to be reja stend Bread as a Food. Changes in its vitime content and nutritive viise with 4 Biological Products. Estilo slitnents “lovniwel for the propagation ani Statistics of Disability. April 14, 116 . By and at coram fiready to A review with reports of observation 21 166 ེབ་ངོས་པར་སuft.l 3. Tertian Malarial Yever. 1. M br, a Mitz |