The Influence of Sodium Benzoate on the Nutrition and Health of Man

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Side 5 - If it contain any added poisonous or other added deleterious ingredient which may render such article injurious to health...
Side 5 - If benzoic acid or any of its salts be mixed or packed with a food, is the quality or strength of said food thereby reduced, lowered, or injuriously affected ? (a) In large quantities ? (b) In small quantities?
Side 6 - As the amount and character of the daily diet exert a well-known influence upon many of the metabolic or nutritive changes of the body, as well as upon the bacterial flora of the intestines, attention is called to the fact that the three investigations differed from each other in the amount of protein food consumed daily, thereby introducing a distinctive feature which tends to broaden the conditions under which the experiments were conducted. The conclusions reached as a result of the individual...
Side 6 - ... under definite conditions of diet, etc., with and without sodium benzoate, were subjected to thorough clinical and medical observation, while the daily food and the excretions were carefully analyzed, and otherwise studied, and comparison made of the clinical, chemical, bacteriological, and other data collected. (For details see the individual reports.) In this manner material has been brought together which makes possible conclusions regarding the effect of small and large doses of sodium benzoate...
Side 7 - Sodium benzoate in large doses (up to 4 grams per day) mixed with the food has not been found to exert any deleterious effect on the general health, nor to act as a poison in the general acceptation of the term.
Side 5 - To obtain satisfactory answers to these questions the board has felt it necessary to carry through a careful investigation of the effect of benzoic acid or some one of its salts on the nutrition and general health of man. A thorough study of the literature giving the results of work done by various investigators on the physiological effects of benzoic acid and its salts, together with a study of reported clinical and medical observations, therapeutic usage, etc., have made it apparent that additional...
Side 6 - ... one that would clearly suffice to show any effect that small doses of the salt might exert, especially if continued for a considerable length of time. In all these four experiments this daily dosage was continued for a period of about two months. Under 'large dose' was included quantities of sodium benzoate ranging from 0.6 gram to 4 grams per day.
Side 6 - To make this experimental inquiry as thorough as possible and to minimize the personal equation, three independent investigations have been carried out; one at the Medical School of Northwestern University in Chicago, under the charge of Prof. John H. Long of that institution ; a second at the private laboratory of Prof. Christian A. Herter of...
Side 7 - The fact should be emphasized that the results obtained from the three separate investigations are in close agreement in all essential features. The main general conclusions reached by the Referee Board are as follows : First.— Sodium benzoate in .small doses (under 0.5 gram per day) mixed with the food is without deleterious or poisonous action and is not injurious to health. Second. — Sodium benzoate in large doses (up to 4 grams per day) mixed with the food has not been found to exert any...
Side 585 - The moderate rise in the proportion of coccal bacteria observed in the fermentation tube sediments after inoculation with the mixed fecal flora...

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