2

Quinidine sulphate, C20 H24 N20%. H, SO4 + 4H,0. Dextrorotatory.

24

2

2

2

Water. Sulphuric acid (p. 202).
Alcohol of 97 per cent. (by vol.) c = 2. t = 15°. [a]o 183. Hesse (L. A. 176,

227).
Quinidine nitrate (p. 205).

Quinidine oxalate, 2 (C2 H2 N, 02). C, H, 04 + H, 0. Dextrorotatory. Alcoholic chloroform. c = 1 to 3. t = 150. [a]” = 189.0 - 2.18 c. Hesse (L. A.

176, 227). Cinchonine, C20 H24 N, O. Dextro-rotatory. Alcohol of 97 per cent. (by vol.) (p. 202). . Alcoholic chloroform. c = 1 to 5. t = 15°. [a], = 238.8 – 1.46 c. Hesse (L. A.

176, 228).
Absolute alcohol. c = 0.5 to 0.75. t = 17°. [a]D 223.3.
Chloroform.

0.455.
| 17°. [4]p 214.8.

Oudemans
C = 0·535.

17o. [a]

212.3. (L. A. 182, 44). 0.560.

17o. [a]o

= 209.6.

2

C =

t

c =

t

-24

2

Cinchonine hydrochloride, C20 H,4 N0.HCl + 2 H20. Dextrorotatory. Water. Hydrochloric acid (p. 202). Alcohol of 97 per cent. (by vol.) c = 1 to 10. 15° [a]D

= 179.81

6.314 c

+ 0.8406 c2 0.0371 6. 80

C = 2.
t = 15°. [a]D

= 188.9.
60

2. 15°. [a]] = 195.5. Alcoholic Chloroform

C = 2.
15°. [a]p
152.0. Hesse (L. A. 176,

231). Dicinchonidine sulphate, 2 (C2H24 N, 0). H, 80, +2 H, 0. Dextro-rotatory.

t =

Cinchonine oxalate, 2 (C20 H24 N20). C, H, 04+2 H,0. Dextrorotatory.

Alcoholic chloroform

= 1 to 3.

t = 15°. [a]o

165.46 - 0•763 c.

Hesse (L. A. 176, 232.)

The changes in the specific rotation of quinine, cinchonine, conchinine and cinchonidine in presence of different proportions of

C = 2.

t =

C = 2.

t =

D

2

2

-2

2

-2

hydrochloric, nitric, chloric, perchloric, formic, acetic, sulphuric, oxalic, and phosphoric acids have been investigated by Oudemans (L. A. 182, 51).

Cinchotenine, C 8 H 20 N,03 + 3H, 0. Dextro-rotatory. Alcoholic chloroform.

15°. [a]

= 115.5. 1 mol. substance + 2 mols. H, SO4 + water. c = 2. t = 150. [a]] 175.5.

Hesse (L. A. 176, 233). Quinicine, C20 H, N, 02. Dextro-rotatory. Chloroform.

15°. [a] 44:1. Hesse (L. A. 178, 260). Quinicine oxalate, 2 (C20 H24 N, 02). C, 1204 + 9 H,0. Dextro

2 rotatory. Alcoholic chloroform. c = 1 to 3.

t = 15°. [a]p 20.68 1:14 c. Water.

C = 2.

t = 15°. [a]u 9.54. 1 mol. salt + 2 mols. H, S 04 + water.

C = 2.
t = 15°. [a] 15.54.

Hesse (L. A. 178, 261).
Cinchonicine, C20 H, N,0. Dextro-rotatory.
Alcohol of 95 per cent. (by vol.) c = 1. = 15°. [a]] 48.
Chloroform.

C = 2.

15°, [a]] 46.5.

Hesse (L. A. 178, 262). Cinchonicine oxalate, 2 (C2, H24 N,0).C, H,04+3 H, 0. Dextro

, rotatory. Alcohol of 97 per cent. (by vol.) c = 2. t = 15°. [a]p = 23.5.

Hesse Alcoliolic chloroform.

c = 1 to 3.
= 15°. [a]] 23.1.

(L. A. 178, Water.

2.
15°. [a]o = 22.6.

263). Water + 2 mols. H, S 04.

2.

15°. [a] 25.75. Quinamine, C2 H2 N, 02. Dextro-rotatory. Alcohol of 96 (?) per cent. (by vol.) c = 0.8378. [a]d = 106.8. Hesse (L. A. 166,

272). Paytine, C2 H24 N, 02. Lævo-rotatory. Alcohol of 96 (?) per cent. (by vol.) c = 0.4542. [a]= 49.5.

Hesse (L. A. 166, 272). Quinidamine (conchinamine), C19H, N, 02 Dextro-rotatory. Alcohol of 97 per cent. (by vol.) c = 1.8.

15°. [a]p

200.

Hesse (D. C. G. 1877, 2158). Geissospermine, C1, H24 N2O2. Lavo-rotatory. Alcohol of 97 per cent. (by vol.) c = 1.5. t = 15°. [a]o 93.4.

Hesse (D. C. G. 1877, 2164). Homocinchonidine, C1, H22 N,0. Lævo-rotatory. Alcohol of 97 per cent. (by vol.) c = 2. t = 15°. [a]. 109.3.

Hesse (D. C. G. 1877, 2156).

t

-26

2

2

-24

t =

Cusconine, C2 H26 N2 O4 + 2 H2O. Lævo-rotatory.

23

2.

t = 15°. [a]D

C = 0·5.

t = 15°. [a]D

=

Alcohol of 97 per cent. (by vol.) c =
Water+3 mols. H Cl

Aricine, C3, H26 N2 O4. Lævo-rotatory.

33

Hesse (L. A. 185, 313.)

Alcohol of 97 per cent. (by vol.) c =

Solution in hydrochloric acid gives no rotation.

OPIUM ALKALOIDS.

Morphine hydrate, C17 H19 N O3 + H2O. Lævo-rotatory.

Solutions in dilute soda. Hesse (L. A. 176, 190). 1 mol. alkaloid + 1 mol. Na, O. c = 2. t: =

Morphine hydrochloride, C17 H19 N Og. HCl + 3 H2O. Lævo

Morphine sulphate, 2 C17 H19 N O ̧ . H2S O4 + 5 H, O.

Morphine acetate, C17 H19 N Og. C2 H4 O2 + 3 H2 0. Lævo

Codeine, C18 H21 N O3 + H2 O. Lævo-rotatory.

Alcohol of 97 per cent. (by vol.)

Codeine hydrochloride, C18 H21 N 03. HCl + 2H, O.

Lævo

Codeine sulphate, 2 C1, H2 N 03. H, SO4 + 5 H, 0. rotatory.

2

-25

C =

t =

t =

+

+

+ 10

+

=

1

+

2

Water. c = 3. t = 15°. [a]n 101.2 )

Hesse (L. A., 176, 191).
c = 3. t = 25°. [a]] 100:9 S
Narcotine, C22 H23 N 0g. Lævo-rotatory.
Alcohol of 97 per cent. (by vol.) c = 0·74. t = 22.5°. [a]o 185.0.
Alcoholic chloroform

2.

22:50. [a]p - .191.5. Chloroform

c = 2 to 5.
| 22:5°. [4]p

207.35.

Hesse (L. A. 176, 192). Narcotine dissolved in hydrochloric acid. Dextro-rotatory. 1 mol. alkaloid + 2 mols. H CI + water

c = 2. [a]

47 0. 1 + 2

c = 5. [a]] 46.4. 1

c = 2. [a]o + 50.0. 2 + alkaloid of 80 per cent.

2. [a]D

+ 104.5. (by vol.) Hesse (L. A. 176, 193). Pseudomorphine hydrochloride, C1, H19 N 04.HCl + H, 0. Lavo-rotatory. 1 mol. salt (c = 0.8 to 1.6) + 1 mol. HCl + water. t = 22:5 [a]D - (114•76

- 4.96 c). 1 mol. salt (c 2) + 51 mols. Na, O + water = 1 mol.

} t = 22:5 [a]p= 198.9. alkaloid + 5 mols. Na, 0 + 1 mol. Na Cl

Hesse (L. A. 176, 195). Thebaine, C, H, N, 03. Lævo-rotatory. Alcohol of 97 per cent. (by vol.) c = 2. t = 15°. [a]. 218.6 97

2. t 25°. [2]D 215.5 Hesse 97

C = 1. t =

22:59. [4]D 216.4 (L. A. 176, 196). Chloroform

22:59. [4]p

- 229.5 Thebaine hydrochloride, C1, H, NO, H Cl + H, 0. Lævo-rotatory. Water. c = 2 to 4. t = 15°. [a]p (168·32 – 2:33 c). c = 2. t = 22:59. [a]o

163.25.
1 mol. salt + 10 mols. HCl + water. c = 2. t = 22:5. [a]] 158.6

Hesse (L. A. 176, 197).
Papaverine, CA , N 04. Lævo-rotatory.
C2 H2

. Alcohol of 97 per cent. (by vol). c = 2. t = 15°. [a]p 4:0. Chloroform.

5. t = 15°. [a]D 5.7.

Hesse (L. A. 176, 198).
Hydrochloride is inactive.
Laudanine, C20 H, N 04 Lævo-rotatory.

25
Chloroform.
2.

22.5. [a

13.5. 1 mol. alkaloid (c 1) + 2 mols. Na, 0 + water. ·

22.5. [a]D

11.4.

Hesse (L. A. 176, 201).
Hydrochloride is inactive.

4

C = 2.

t

Laudanosine, C2 H, NO, Dextro-rotatory.

. Alcohol of 97 per cent. (by vol.) c = 2:79. t = 15°. [a]]

= 103.2. 97

22.5. [a]n

= 105.0. Chloroform.

2. t = 22.5. [a]o 56.0. 1 inol. alkaloid (c = 2) + 2 mols. H Cl + water. t = 22.5. [a], 108.4.

Hesse (L. A. 176, 202). Narceine, hydrocotarnine, cryptopine, meconine are inactive.

C=

STRYCHNINE ALKALOIDS.

Strychnine, C21 H, N20.2. Lævo-rotatory.

-22
Alcohol. d 0.865. c = 0.91. [a] 128.
Chloroform.

C = 4.
[a], 130.

Oudemans
3 = 2.25. [a], - 137.7.

(L. A. 166, 76).
= 1.5.
[a],

- 140.7. Amyl alcohol.

C = 0.53. [a], 235.
Brucine, C2 H2 N,0. Lævo-rotatory.

, 04 Alcohol.

c = 5.4.
[a]p

85. Chloroform.

Oudemans
C = 1.9.
[a]] 127.

(L. A. 166, 69).
C = 4.9. [a], 119.

}

$ 121. Unclassified Vegetable Substances.

t

C =

t =

C=

15

3

Santonin, C1, H18 03. Lævo-rotatory.

Alcohol. 2. 20. [a]s 230. Buignet (J. d. Pharm. et de chim. [3] 40, 252). This substance is characterized by very marked rotatory dispersion. Alcohol of 97 per cent. (by vol.) c = - 2. t = 15°. [a]o · 174.0. 90

C = 2.

t = 15°. [a], 175.4. Hesse (L. A. 80

2.
15°. [4]p

176.5. 176, 125). Chloroform.

2 to 10. t = 15°. [a]!

171.5. Bichloro-santonin, C1, H16 C1, Og. Lævo-rotatory. Alcohol of 97 per cent. (by vol.) c = 1. t= 15°. [a]] 23. Hesse (loc. cit). Santonic acid, C H200 Lævo-rotatory.

, % Alcohol of 97 per cent. (by vol.) c = 1 to 3. t = 22.5°. [a], 25.8. Hesse 80

2
3. t = 22:59. [4]p

26.5. (loc. cit).
Santonate of soda, 2 (C1H1, Na 04) + 7H,0. Lævo-rotatory.
Water. b = 2 to 6. t = 22.5°. [a]o (18.70 + 0.33 c).
The rotation decreases with increase of temperature. At 25°, with c =

3 [a] 20.0, and with c =

10 [a] 21.7. Hesse (loc. cit). Picrotoxin, C12 H14 Og Lævo-rotatory. Alcohol. p = 3•125. [a], 28.1. Bouchardat and Boudet (J. Pharm. chim. [3]

}

C