Quinidine sulphate, C20 H24 N2 02. H2SO4 + 4 H, O. Dextro

rotatory.

Water. Sulphuric acid (p. 202).

2

Alcohol of 97 per cent. (by vol.) c = 2.

t = 15°. [a]D

=

183. Hesse (L. A. 176, 227).

Quinidine nitrate (p. 205).

Quinidine oxalate, 2 (C20 H24 N2 O2). C2 H2 O4 + H2 0. Dextro

rotatory.

Alcoholic chloroform. c = 1 to 3.

t =

15°. [a] = 189.0 - 2.18 c.

Hesse (L. A. 176, 227).

Cinchonine, C20 H24 N2 O. Dextro-rotatory.

Alcohol of 97 per cent. (by vol.) (p. 202)..
Alcoholic chloroform. c = 1 to 5.

t = 15°. [a]D

= 238.8

1.46 c. Hesse (L. A. 176, 228).

Cinchonine hydrochloride, C2 H24 N, O. H Cl + 2 H2O. Dextro

[a]D:

214.8.

[a]D

212.3.

[a]D

=

209.6.

t = 15°.

[a]D = 179.81
+ 0.8406 c2

6.314 c

0.0371 c3.

Dicinchonidine sulphate, 2 (C20 H24 N2 O) . H2 SO4 + 2 H2O. Dex

Cinchonine oxalate, 2 (C20 H24 N2 O) . C2 H2 O4 + 2 H2O. Dextro

rotatory.

2 2

Alcoholic chloroform c = 1 to 3. t = 15°. [a]D = 165.46 0.763 c.

Hesse (L. A. 176, 232.)

The changes in the specific rotation of quinine, cinchonine, conchinine and cinchonidine in presence of different proportions of

hydrochloric, nitric, chloric, perchloric, formic, acetic, sulphuric, oxalic, and phosphoric acids have been investigated by Oudemans (L. A. 182, 51).

2

2

Cinchotenine, C18 H20 N2 O3 + 3 H, O. Dextro-rotatory. Alcoholic chloroform. c = 2. t = 15°. [a]D 1 mol. substance + 2 mols. H2 SO4 + water.

= 115.5.

c = 2. t = 15°. [a]D = 175.5. Hesse (L. A. 176, 233).

Quinicine, C20 H24 N2 O2. Dextro-rotatory.

Chloroform. c = 2.

2

t = 15°. [a] = 44 1. Hesse (L. A. 178, 260).

Quinicine oxalate, 2 (C20 H24 N2 O2). C2 H2 O4 + 9 H2 O. Dextro

2

t = 15°. [a]D = 20.68

1 mol. salt + 2 mols. H, S O4 + water.

Cinchonicine, C20 H24

1.14 c.

= 15.54.

15°. [a]v
c = 2.

Alcohol of 95 per cent. (by vol.) c = 1.
Chloroform.

= 46.5.

Hesse (L. A. 178, 262).

Cinchonicine oxalate, 2 (C2, H24 N2 O). C2 H2O4 + 3 H2O. Dextro

Quinamine, C2 H26 N2 O2. Dextro-rotatory.

Alcohol of 96 (?) per cent. (by vol.) c = 0.8378. [a]D = 106 8. Hesse (L. A. 166,

Paytine, C21 H24 N2 O2. Lævo-rotatory.

272).

Alcohol of 96 (?) per cent. (by vol.) c = 0·4542. [a]D

= 49.5.

Hesse (L. A. 166, 272).

Quinidamine (conchinamine), C19 H24 N2 O2. Dextro-rotatory.

Geissospermine, C19 H21 N2 O2.
Alcohol of 97 per cent. (by vol.) c = = 1.5. t = 15°. [a]D

Homocinchonidine, C1, H22 N2 O.

19

= 93.4.

Hesse (D. C. G. 1877, 2164).

Lævo-rotatory.

Alcohol of 97 per cent. (by vol.) c = 2. t = 15°. [a]D

= 109.3.

Hesse (D. C. G. 1877, 2156).

R

Cusconine, C2 H26 N2 O4 + 2 H2O. Lævo-rotatory.

23

с =

Hesse

54 3 (L. A. 185,303.) 71.8

[α]D 15°. [a]D

t =

C = 0.5.

15°. [a]D t = 15°. [a]D

=

Morphine hydrate, C17 H19 N O3 + H2O. Lævo-rotatory.

Solutions in dilute soda. Hesse (L. A. 176, 190).

1 mol. alkaloid + 1 mol. Na2 O.

Morphine hydrochloride, C17 H19 N O ̧ . H Cl + 3 H, O. Lævo

Morphine sulphate, 2 C17 H19 N Og. H2SO4 + 5 H2O. Lævo

rotatory.

2

(100.47 0.96 c). Hesse (L. A. 176, 190).

Morphine acetate, C17 H19 NO. C2 H4 O2 + 3 H, O.

Codeine, C18 H21 NO3 + H, O. Lævo-rotatory.

Alcohol of 97 per cent. (by vol.)

Lævo

Chloroform

Hesse (L. A. 176, 191).

Codeine hydrochloride, C18 H21 N O3. HCl + 2 H2O.

Codeine sulphate, 2 C18 H21 N O3. H2SO, + 5H, O.

rotatory.

Water. c = 3.

4

Lævo

t = 15°. [a]n
25°. [a]D

= 100.9

Lævo-rotatory.

t =

22.5°. [a]D
[a]D

t = 22·5°.

=

..191.5.

-
= 207.35.

Hesse (L. A. 176, 192).

Hesse (L. A., 176, 191).

[a]D

Narcotine dissolved in hydrochloric acid. Dextro-rotatory.

Pseudomorphine hydrochloride, C17 H19 NO4. HCl + H2O.

Lævo-rotatory.

1 mol. salt (c = 0.8 to 1·6) + 1 mol. H Cl + water.

1 mol. salt (c alkaloid

2)+5 mols. Na, O+ water = 1 mol. 5 mols. Na2 O + 1 mol. Na Cl

Thebaine, C19 H21 N2 Og. Lævo-rotatory.

2

Alcohol of 97 per cent. (by vol.) c = 2. t

t = 22·5 [a]D=
Hesse (L. A. 176, 195).

Chloroform

-

Hesse

216.4 (L. A. 176, 196).

= 229.5

Thebaine hydrochloride, C19 H21 NO, H Cl + H2 O. Lævo-rotatory.

Laudanosine, Cal H27 NO4. Dextro-rotatory.

C21

Narceine, hydrocotarnine, cryptopine, meconine are inactive.

STRYCHNINE ALKALOIDS.

Strychnine, C2 H22 N2 O2. Lævo-rotatory.

Alcohol. d = 0.865.
Chloroform.

21

c = 0·53.

Brucine, C23 H26

130.

- 137.7.

140.7.

= 235.

N2O4. Lævo-rotatory.

Oudemans

(L. A. 166, 76).

Oudemans

(L. A. 166, 69).

§ 121. Unclassified Vegetable Substances.

Santonin, C15 H18 Og. Lævo-rotatory.

Alcohol. c = 2. t = 20. [a];

=

230. Buignet (J. d. Pharm. et de chim. [3] 40, 252). This substance is characterized by very marked rotatory dispersion.

Bichloro-santonin, C15 H16 Cl2 O3. Lævo-rotatory.

2

Alcohol of 97 per cent. (by vol.) c = 1. t= 15°. [α]D

Santonic acid, C15 H20 O4.

Santonate of soda, 2 (C15 H19 Na 04) + 7 H2 O. Lævo-rotatory.

The rotation decreases with increase of temperature. At 25°, with c = 20.0, and with c = 10 [a] = 21.7. Hesse (loc. cit).

3 [a]D

Lævo-rotatory.

Alcohol. p 3·125. [a];

=

28.1. Bouchardat and Boudet (J. Pharm. ehim. [3] 23, 288).