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Quinidine sulphate, C20 H24 N20%. H, SO4 + 4H,0. Dextrorotatory.

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Water. Sulphuric acid (p. 202).
Alcohol of 97 per cent. (by vol.) c = 2. t = 15°. [a]o 183. Hesse (L. A. 176,

227).
Quinidine nitrate (p. 205).

Quinidine oxalate, 2 (C2 H2 N, 02). C, H, 04 + H, 0. Dextrorotatory. Alcoholic chloroform. c = 1 to 3. t = 150. [a]” = 189.0 - 2.18 c. Hesse (L. A.

176, 227). Cinchonine, C20 H24 N, O. Dextro-rotatory. Alcohol of 97 per cent. (by vol.) (p. 202). . Alcoholic chloroform. c = 1 to 5. t = 15°. [a], = 238.8 – 1.46 c. Hesse (L. A.

176, 228).
Absolute alcohol. c = 0.5 to 0.75. t = 17°. [a]D 223.3.
Chloroform.

0.455.
| 17°. [4]p 214.8.

Oudemans
C = 0·535.

17o. [a]

212.3. (L. A. 182, 44). 0.560.

17o. [a]o

= 209.6.

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Cinchonine hydrochloride, C20 H,4 N0.HCl + 2 H20. Dextrorotatory. Water. Hydrochloric acid (p. 202). Alcohol of 97 per cent. (by vol.) c = 1 to 10. 15° [a]D

= 179.81

6.314 c

+ 0.8406 c2 0.0371 6. 80

C = 2.
t = 15°. [a]D

= 188.9.
60

2. 15°. [a]] = 195.5. Alcoholic Chloroform

C = 2.
15°. [a]p
152.0. Hesse (L. A. 176,

231). Dicinchonidine sulphate, 2 (C2H24 N, 0). H, 80, +2 H, 0. Dextro-rotatory.

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Cinchonine oxalate, 2 (C20 H24 N20). C, H, 04+2 H,0. Dextrorotatory.

Alcoholic chloroform

= 1 to 3.

t = 15°. [a]o

165.46 - 0•763 c.

Hesse (L. A. 176, 232.)

The changes in the specific rotation of quinine, cinchonine, conchinine and cinchonidine in presence of different proportions of

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hydrochloric, nitric, chloric, perchloric, formic, acetic, sulphuric, oxalic, and phosphoric acids have been investigated by Oudemans (L. A. 182, 51).

Cinchotenine, C 8 H 20 N,03 + 3H, 0. Dextro-rotatory. Alcoholic chloroform.

15°. [a]

= 115.5. 1 mol. substance + 2 mols. H, SO4 + water. c = 2. t = 150. [a]] 175.5.

Hesse (L. A. 176, 233). Quinicine, C20 H, N, 02. Dextro-rotatory. Chloroform.

15°. [a] 44:1. Hesse (L. A. 178, 260). Quinicine oxalate, 2 (C20 H24 N, 02). C, 1204 + 9 H,0. Dextro

2 rotatory. Alcoholic chloroform. c = 1 to 3.

t = 15°. [a]p 20.68 1:14 c. Water.

C = 2.

t = 15°. [a]u 9.54. 1 mol. salt + 2 mols. H, S 04 + water.

C = 2.
t = 15°. [a] 15.54.

Hesse (L. A. 178, 261).
Cinchonicine, C20 H, N,0. Dextro-rotatory.
Alcohol of 95 per cent. (by vol.) c = 1. = 15°. [a]] 48.
Chloroform.

C = 2.

15°, [a]] 46.5.

Hesse (L. A. 178, 262). Cinchonicine oxalate, 2 (C2, H24 N,0).C, H,04+3 H, 0. Dextro

, rotatory. Alcohol of 97 per cent. (by vol.) c = 2. t = 15°. [a]p = 23.5.

Hesse Alcoliolic chloroform.

c = 1 to 3.
= 15°. [a]] 23.1.

(L. A. 178, Water.

2.
15°. [a]o = 22.6.

263). Water + 2 mols. H, S 04.

2.

15°. [a] 25.75. Quinamine, C2 H2 N, 02. Dextro-rotatory. Alcohol of 96 (?) per cent. (by vol.) c = 0.8378. [a]d = 106.8. Hesse (L. A. 166,

272). Paytine, C2 H24 N, 02. Lævo-rotatory. Alcohol of 96 (?) per cent. (by vol.) c = 0.4542. [a]= 49.5.

Hesse (L. A. 166, 272). Quinidamine (conchinamine), C19H, N, 02 Dextro-rotatory. Alcohol of 97 per cent. (by vol.) c = 1.8.

15°. [a]p

200.

Hesse (D. C. G. 1877, 2158). Geissospermine, C1, H24 N2O2. Lavo-rotatory. Alcohol of 97 per cent. (by vol.) c = 1.5. t = 15°. [a]o 93.4.

Hesse (D. C. G. 1877, 2164). Homocinchonidine, C1, H22 N,0. Lævo-rotatory. Alcohol of 97 per cent. (by vol.) c = 2. t = 15°. [a]. 109.3.

Hesse (D. C. G. 1877, 2156).

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Cusconine, C23 H.26 N204 + 2 H, 0. Lævo-rotatory. Ether (d = 0·72)

C = 1.

t = 15°. [a]p · 27:1 2.

15°. [a] 26.8 Hesse Alcohol of 97 per cent. (by vol.) c = 2.

15°. [a] 54 3 ( (L. A. 185,303.) Water + 3 mols. H CI

c = 05.
t = 15°. [a]o

71.8
Aricine, C33 H26 N, 04. Lævo-rotatory.
Ether (d
0.72)

c = 1 to 2.5. t = 15°. [a]] 94.7. Alcohol of 97 per cent. (by vol.) c = 1.

15°. [a]p · 54:1.

Hesse (L. A. 185, 313.) Solution in hydrochloric acid gives no rotation.

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Morphine hydrate, C1, H1, N 03 + H2O. Lævo-rotatory. Solutions in dilute soda. Hesse (L. A. 176, 190). 1 mol. alkaloid + 1 mol. Na, 0, 6 = 2. t = 22.5. [a]] 67.5. 1 + 5

2. t = 22.5. [a], - 70.2. 1 + 2 5. t 22:5. [a]]

71.0. Morphine hydrochloride, C1, H 9 N 0g. HCl + 3 H, 0. Lavorotatory. Water, c= 1 to 4. 15°. [a]p

(100:67 - 1.14 c). Water + 10 mols. H Cl. c = 2. t = 15°.

[a], - 94:3. Hesse (L. A. 176, 190). Morphine sulphate, 2 C1, H1, N 03. H,S 04 + 5 H,0. Lævorotatory. Water. c = 1 to 4. t = 15°. [a]} - (100•47 0.96 c). Hesse (L. A. 176, 190).

Morphine acetate, C1, H19 N 03 . C2H4O2 + 3 H2 0. Lævorotatory. Absolute alcohol.

1.2. [a] 100.4. Alcohol d = 0·865. c= 0.97. [a] 98.9.

Oudemans Water. c = 2:5. [a] 77.

(L. A. 166, 77). c = 0.996. [a] 72. Codeine, C18 H2 N 03 + H20. Lævo-rotatory. Alcohol of 97 per cent. (by vol.) C = 2 to 8. t = 15°. [a] 135.8. 80

2. t = 15°. [a]] 137.8. Chloroform

C = 2.

t = 15°. [a]n 111.5.

Hesse (L. A. 176, 191). Codeine hydrochloride, C8H2 N 03.HCl + 2 H, 0. Lavorotatory. Water.

2. t = 22:50. [a]] 108.2. 1 mol. salt + 10 mols. HCl + water. 2.

22 5o. [a]p

105.2. Alcohol of 80 per cent. (by vol.)

C = 2.
22:50. [a] . 108.

Hesse (loc. cit.)

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Codeine sulphate, 2 C13 H2 N 03. H, SO4 + 5 H, 0. Lavorotatory. Water.

c = 3.

t = 15°. [a]n 101.2
C = 3.
t = 25°. [a]p

100-3} Hesse (L. A., 176, 191).
Narcotine, C22 H25 N 07. Lævo-rotatory.
Alcohol of 97 per cent. (by vol.)

C = 0.74. t = 22.5°. [a] 185.0. Alcoholic chloroform

C = 2..

22.5°. [a]

- .191.5. Chloroform

c = 2 to 5. t = 225o. [a] 207.35.

Hesse (L. A. 176, 192). Narcotine dissolved in hydrochloric acid. Dextro-rotatory. 1 mol. alkaloid + 2 mols. H Cl + water

c = 2. [a] 47 0. 1 + 2

c = 5. [a]p 46.4. 1 + 10

2. [a]o

50.0. 1 + 2 + alkaloid of 80 per cent. c = 2. [a]

+ 104.5. (by vol.) Hesse (L. A. 176, 193). Pseudomorphine hydrochloride, C1, H19 N 04.HCl + H, 0. Lævo-rotatory. 1 mol. salt (c 0.8 to 1.6) + 1 mol. HCl + water. t = 22:5 [a]D (114.76

– 4.96 c). 1 mol. salt (c 2) + 51 mols. Na, 0 + water = 1 mol.

198.9. alkaloid + 5 mols. Na, 0 + 1 mol. Na Cl

t = 22:5 [a]o=

Hesse (L. A. 176, 195).
Thebaine, C, H, N, 03. Lævo-rotatory.
Alcohol of 97 per cent. (by vol.) c = 2. t 15°. [a]. 218.6
97

2. t
25o. [2]p 215.5

Hesse
97

c = l. t = 22:59. [4]D 216.4 (L. A. 176, 196). Chloroform

c = 5. t =
22:59. [4]p

229.5 Thebaine hydrochloride, C1, H2 NO, HCl + H, 0. Lævo-rotatory. Water. 2 to 4. t = 15°. [a]D

(168.32

2:33 c).
2.
22:5o. [a]o

16325.
1 mol. salt + 10 mols. HCl + water. c = 2. t = 22.5. [a]p 158.6

Hesse (L. A. 176, 197). Papaverine, C2 H2 N 04. Lævo-rotatory. Alcohol of 97 per cent. (by vol). c = 2. t = 150. [a]o

4:0. Chloroform.

15°. [a]o

5.7.

Hesse (L. A. 176, 198).
Hydrochloride is inactive.

Laudanine, C20 H2 N 04 Lævo-rotatory.
Chloroform.
C = 2.

22.5. [a 13.5. 1 mol. alkaloid (c 1) + 2 mols. Na, 0 + water.

22:5. [a]o

11.4.

Hesse (L. A. 176, 201).
Hydrochloride is inactive.

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C = 2.

t =

Laudanosine, C, H, NO4. Dextro-rotatory.

, Alcohol of 97 per cent. (by vol.) c = 2.79. t = 15°. [a] 103.2. 97

22-5. [a]n

105.0. Chloroform.

C = 2.

t = 22.5. [a]o 56.0. 1 inol. alkaloid (c 2) + 2 mols. H Cl + water. t = 22.5. [a] 108.4.

Hesse (L. A. 176, 202). Narceine, hydrocotarnine, cryptopine, meconine are inactive.

STRYCHNINE ALKALOIDS.

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Strychnine, C2 H2 N, 02. Lævo-rotatory.
Alcohol. d = 0.865. c = 0.91. [a]] 128.
Chloroform.
4. [a], 130.

Oudemans
2 = 2.25. [a] 137.7.

(L. A. 166, 76). 1.5. [a], 140.7. Amyl alcohol.

0:53. [a],

235. Brucine, C23 H26 N,Of. Lævo-rotatory. Alcohol.

C= 5.4.

[a] 85. Chloroform.

Oudemans c = 1.9. [a] 127.

(L. A. 166, 69). C = 4.9. [a], 119.

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§ 121. Unclassified Vegetable Substances.

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Santonin, CH18 03. Lævo-rotatory. .

Alcohol. 2. t = 20. [a]; 230. Buignet (J. d. Pharm. et de chim. [3] 40, 252). This substance is characterized by very marked rotatory dispersion. Alcohol of 97 per cent. (by vol.) c = = 2.

15°. [a]]

174.0. 90

15°. [a],

175.4. Hesse (L. A. 80

2.
15o. [a]p

176.5. 176, 125). Chloroform.

2 to 10. t 15°. [a]o

171.5. Bichloro-santonin, C6H6C1, 03. Lævo-rotatory.

-Og Alcohol of 97 per cent. (by vol.) c = 1. ti= 15°. [a]] = 23. Hesse (loc. cit). Santonic acid, C; H200 Lævo-rotatory.

% Alcohol of 97 per cent. (by vol.) c = 1 to 3. t = 22.5°. [a], 25.8. Hesse

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80

2
3. t =
22:59. [4]p

26.5. (loc. cit). Santonate of soda, 2 (C1: H1, Na 04) + 7H, O. Lævo-rotatory. Water. b = 2 to 6. t = 22:5°. [a], (18.70 + 0•33 c).

The rotation decreases with increase of temperature. At 25°, with c = 3 [a]p 20:0, and with c = 10 [a] = 21.7. Hesse (loc, cit).

Picrotoxin, C12 H 4 Oz Lævo-rotatory. Alcohol. p = 3.125. [alj 28.1. Bouchardat and Boudet (J. Pharm. bhim. [3]

23, 288).

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