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CHOLERA, PLAGUE, SMALLPOX, TYPHUS FEVER, AND YELLOW

FEVER—Continued.

Reports Received from June 30 to July 27, 1923—Continued.
PLAGUE—Continued.

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CHOLERA, PLAGUE, SMALLPOX, TYPHUS FEVER, AND YELLOW

FEVER— Continued.

Reports Received from June 30 to July 27, 1923—Continued.

SMALLPOX—Continued.

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CHOLERA, PLAGUE, SMALLPOX, TYPHUS FEVER, AND YELLOW

FEVER—Continued.

Reports Received from June 30 to July 27, 1923—Continued.
SMALLPOX—Con tinned.

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CHOLERA, PLAGUE, SMALLPOX, TYPHUS FEVER, AND YELLOW

FEVER—Continued.

Reports Received from June 30 to July 27, 1923—Continued.
TYPHUS FEVER—Continued.

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PUBLIC HEALTH REPORTS

VOL. 38 AUGUST 10, 1923 No. 32

THE CURATIVE ACTION OF SULPHARSPHENAMINE IN EXPERIMENTAL SYPHILIS.

By Tael Voegtltn, Professor of Pharmacology, C. Armstrong, Passed Assistant Surgeon, and Helen A. Dter. Assistant Pharmacologist, Hygienic Laboratory, United States Public Health Service.

In a previous paper by Voegtlin, Johnson, and Dyer (1922), experiments were reported which showed that treatment with single doses of sulpharsphenaminc (15 to 50 mg. per kilo) leads to a prompt disappearance of Treponema pallidum from the scrotal lesions in rabbits and causes a marked improvement of these lesions. From the practical standpoint of the efficacy of sulpharsphenamine in the treatment of human syphilis, it is, of course, important to know whether this drug is able to sterilize the animal, i. e., to cause the death of all tho parasites. The question is, What shall be the criterion of sterilization? Clinical relapse usually occurs after a sufficiently long time has elapsed following treatment with subcurative doses, but this criterion alone furnishes insufficient proof, and, furthermore, requires a very long period of observation.

Pearce and Brown (1922) have recently shown that Treponema

pallidum has a strong tendency to localize in lymph glands, and in

the experience of these investigators, transplantation of macerations

of lymph glands into the scrotum of normal rabbits yields fairly good

evidence as to the presence or absence of syphilitic infection in the

donor. We have, therefore, used this method on some of our rabbits

treated with sulpharsphenamine and neoarsphenamine. The control

numbers of these rabbits are the same as those given in the previous

paper. Unfortunately, three of the animals (Nos. 4, 6, and 7) died of

intercurrent infections before transplants could be made. However,

in none of these three animals was there any recurrence of syphilitic

lesions before death occurred. The history of these three rabbits is,

briefly, as follows:

Rabbit No. -(.—October 23, 1922: Scrotal lesions completely healed. November 29 sixty -fifth day following treatment with 27 mg. neoarsphenamine per kilo): Animal has developed an infection of the respiratory tract, causing a purulent nasal discharge; chloroformed. Necropsy: Both testicles normal: infectious process of upper respiratory tract; mucous membrane of trachea congested and hemorrhagic; no other gross leaiooa.

55083°—23 1 (1815)

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