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series of 230 cases, 2 died as a result of the injections, one of accidental sepsis, and the other from "too rapid disintegration of the growth"; 13 survived the three-year limit presumed to denote a cure; 1 relapst and died in 3 years after discontinuance of the treatment, thus proving the diagnosis; 1 lived 7 years after discontinuance of treatment, 3 lived over 6 years, 2 over 5 years, 7 over 3 years, and 4 over 2 years. Recurrence was noted in 3 cases which had shown decided improvement, still further confirming his diagnostic ability. Of the 35 cases treated by others, in 26 instances the tumors disappeared, and 14 patients were yet living after 2 to 4 years had elapst. Others following Coley's directions have failed to obtain equally good results.

The spindle-celled sarcoma seems to be most amenable to this treatment. They, as is well known, are least malignant in type, and more nearly resemble organized tissue in their structure. The melanotic sarcoma fails to respond to the injections. Coley does not recommend his treatment in any but inoperable cases, and in this class it would seem well worthy of a trial. Coley offers the explanation that malignant tumors are parasitic in origin, and that his erysipelas serum has an antagonism for such parasities. It will be remembered in this connection that syphilis and tuberculosis have shown improvement after an attack of erysipelas.

Emmerich and Scholl attempted to utilize erysipelas germs against malignant tumors by inoculating sheep with the streptococcus erysipelatis, and from such animals extracting a serum which they use on their patients. They obtained improvement in symptoms, but failed to record any cures, for altho signs of softening of the tumors were noted, still the patients died despite the treatment.

Wlaeff and d'Hotman de Villiers obtained cultures of blastomycetes from cancerous growths, and inoculated pigeons with them. Serum was taken from the inoculated birds and injected into the bodies of rats as a prophylactic against the cancer from which these animals suffer. The same plan has been tried in the human subject, and Wlaeff states that it induces the leukocytes to surround, penetrate, and destroy isolated epithelial cells. Reynier says that the serum relieves pain and produces a general improvement in the condition of the patient, but that the progressiv growth of the tumor is uninfluenced. It is considerable of a test on one's credulity to ask that they believe that any such serum can influence human cancer favorably.

Doyen isolated from malignant tumors an organism which he called micrococcus neoformans, and manufactured an antagonistic serum from it by passing it thru animals. He employed it in treating cancer, injecting it into the buttocks. In his 126 cases, 58

showed no improvement, 18 were classed as "on the way to cure," 29 improved, and in 21 instances the growth disappeared. There is no record of any test of this serum having been made by others.

Dubois macerated malignant tumors and injected them into animals, and from the animals took a serum which he declared had power to induce fibrosis in new-celled growths. Leyden and Blumenthal injected rabbits with finely divided tumors taken from dogs, and believed dogs suffering from tumors were benefited by injections of the serum of such inoculated rabbits. They experimented on human subjects, using carcinomatous cells from human subjects in production of the serum, and believed that benefit followed in some inoperable cases.

Adamkiewicz has prepared an extract from cancers which is declared to consist of neurine combined with a preservativ fluid; he has made astonishing claims, which have been seconded by Kretzmer, but Nothnagel attacks his reports with the assertion that he failed to establish a complete diagnosis in any of his cases. He calls his product "Cancroin," but the profession has failed to take him or the "juice" seriously.

It is noteworthy that all of these experimenters have reported good results in their own hands, but that none of such results have ever been duplicated by others. Coley's idea is the only one that is now being followed to any extent, and it only after operation or in inoperable cases; here it is certainly worthy of trial, but it should not be used to the delay of operation. Until cancer be proven an infectiv disease no effectiv serum treatment along the ordinary serum treatment line can be reasonably hoped for, but it is possible that a cytolytic serum may yet be produced which will be inimical to the growth of the cancer cell, and yet be harmless to the normal cells of the adjacent tissues.

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percent aqueous solution of methylene-blue is serviceable.

In chronic eczema with infiltration and thickening of the affected tissues, a thoro painting with equal parts of ichthyol and water, and permitting it to dry on the skin, and then following with a film of flexible collodion, will often be satisfactory to physician and pleasing to the patient.

Ten grains of resorcin to the ounce of pure bay rum makes a valuable hair and scalp dressing in eczematous dandruff of the adult. It is severe for a moment if eruption or ulceration is present, but a soothing sensation is quickly made manifest thereafter. If the hair is falling out, a few grains of common table salt may be incorporated to each ounce.

In cases of eczema or other skin disease of suspected parasitic etiology the following inunction will be found to be an efficient parasiticide capable of deep penetration without the necessity of inducing previous exfoliation of the epidermis: Mix equal quantities of the tinctures of juniperus oxycedrus, stavesacre, pinus silvestris, and eugenia caryophylata. This should be weakened with water or glycerin in the early applications, and is not to be combined with animal fats. It is harmless to the tissues, and allays itching and irritation almost immediately.

The oil of cade is too often forgotten in eczema. It is old-fashioned, but its powers for good are not exhausted.

Hidden Dangers Must Be Revealed. The new food law provides that medicins shall be considered misbranded "if the package fail to bear a statement on the label of the quantity or proportion of any alcohol, morphin, opium, cocain, heroin, alpha eucain or beta eucain, chloroform, cannabis indica, chloral hydrate, or acetanilid, or any derivativ or preparation of any such substances contained therein." And this is now actually a law! It is almost too good to believe. How about the soothing syrups, alcohol tipples and actenalid mixtures, etc., now? Let's watch them.

Will Doctors Never Learn?

When will doctors give up the speculating habit? A Canadian brother writes asking if it would be safe to invest in a certain "development" company, operating on certain lands in the tropics. Altho I am not a consultant concerning individual investments, and don't like to be bothered by being askt about them, I wrote him saying that a man who puts say $100 or $1000 into that kind of an investment may be made to think that he is getting good returns for several years, but he will seldom live to see all of his $100 or $1000 come back to him. Remember that the Storey Cotton Co. paid good dividends, and made their victims think they were getting rich. The fact is, they paid

dividends out of the money that came in (that is, out of capital instead of profits, which is against the law). The fact that good dividends came in stimulated the victims to raise more money and send it in, and get their friends in on a "good thing." Thus several millions got into the hands of the schemers, which they got away with. When you loan your money on good real estate in your vicinity, your investment has a safe and tangible basis. You will always get your interest, and you or your heirs will get the principal back again; but when you invest where there is no basis except the “hot air" of schemers, as some far-away tropical plantation, or mine, or oil well, you will almost always lose your principal, and what you get back in dividends will amount to only a fraction of the principal-really only interest for several years, after which all is gone. Can't you see the difference?

A Tonic for the Doctor.

A Boston firm offered a prize of $250 for the best answer to the question, "What constitutes success?" Mrs. A. J. Stanley, of Lincoln, Kan., won the prize. This was her

answer:

"He has achieved success who has lived well, laughed often and loved much; who has gained the respect of intelligent men and the love of little children; who has filled his niche and accomplisht his task; who has left the world better than he found it, whether by an improved poppy, a perfect poem or a rescued soul; who has never lackt appreciation of earth's beauty or failed to express it; who has always lookt for the best in others and given the best he had; whose life was an inspiration; whose memory a benediction."

When you get blue, this will be a good tonic-not only for doctors, but for all other men and women. Try it on your hypochondriacs. This ought to bring them out of themselves.

Can you improve on the above answer to "What constitutes success?" Can you add anything to it? But what is much more important, can we live it?

"Stop Antikamnia Adv. or Journal."

DR. C. F. TAYLOR; DEAR DOCTOR:-Inclosed find check for $3, for which give credit. When gone, draw on me for $3 more until ordered to stop.

I received a card from the New York Medical Journal (had been taking Medical News) to sign for continuance of my subscription. I wrote on it: "Stop antikamnia adv. or journal." This was three months ago; have not heard from them since. Valparaiso, Neb.

J. D. GUTTERY. Here we have a discriminating doctor, and one who makes his influence felt. Why should not every doctor make his influence

felt? Do doctors think that there should be some supervision over the advertisements admitted to medical periodicals? If so, where should we begin? How many have been convinced by our exposures that a beginning should be made by excluding antikamnia from the advertising pages of respectable medical publications? If you have been convinced, why not say so in an effectiv way, like Doctor Guttery, and make your influence felt? True, Doctor Guttery did not get antikamnia out of the New York Medical Journal, but if several hundred had joined him in the demand, it would have been done. I could not have cleaned up the Medical Brief if the profession had not joined, sustained and aided me. The profession can do anything it wants to with its own literature; it can make any demands it sees fit, and they must be heeded, if the demands are made strong enuf.

THE MEDICAL WORLD is a democratic medical journal; that is, it goes to the great democracy of the profession. Democratic means ruled by the people; a democratic profession means a profession ruled by the profession. We have no sympathy with those conspicuous teachers who teach one thing and do the opposit. The great leaders who talk ethics but who leave the practise of ethics to the men in the ranks, should be unstintingly condemned, and without ceasing, until they reform. Do you think that promoting the interests of antikamnia is becoming to any who stand high in the councils of the profession, and who stand in the relation of "professor" to the rising profession? Please look carefully over the following list of journals that carry the antikamnia advertisement, and note the editors of some of them:

The Great Weeklies:

The New York Medical Record.

The New York Medical Journal (with which the Philadelphia Medical Journal and the Medical News are now consolidated). The Boston Medical and Surgical Journal.

The State Organization Journals:

Journal of the Mississippi State Medical Society. Journal of the Minnesota State Medical Society. Western Medical Review, the Journal of the Nebraska State Medical Association.

Other Journals:

American Journal of the Medical Sciences ($5 per year; publisht by Lea Bros. & Co.).

Surgery, Gynecology and Obstetrics ($5 per year; the great surgeons, Senn and J. B. Murphy on the staff).

Annals of Surgery ($5 per year; J. Wm. White and other great surgeons on the staff).

American Journal of Obstetrics ($4 per year).

Therapeutic Gazette (edited by H. A. Hare, the author of medical books and a professor in Jefferson Medical College, and Edward Martin, a professor in the Medical Department of the University of Pennsylvania).

The Lancet-Clinic.

The Medical Standard.

The Post-Graduate.

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Medical Review of Reviews.

Medical Herald.

Merck's Archives.

Charlotte Medical Journal.

Medical Times.

Monthly Cyclopedia of Practical Medicine.
Medical Sentinel.

Medico-Chirurgical Journal.
Columbus Medical Journal.
Medical Era.

Regular Medical Visitor.

Los Angeles Medical Journal.
Medical Examiner and Practitioner.
Massachusetts Medical Journal.
Gaillard's Southern Medicine.
Kansas City Medical Record.
Milwaukee Medical Journal.
Buffalo Medical Journal.
Providence Medical Journal.
Memphis Medical Monthly.

Medical Progress, Louisville, Ky.

St. Louis Medical and Surgical Journal.
Southern Practitioner.

Pacific Medical Journal.

Wisconsin Medical Recorder.

St. Louis Courier of Medicine.
Nashville Journal of Medicine and Surgery.
Virginia Medical Semi-Monthly.
Vermont Medical Monthly.
Brooklyn Medical Journal.
Northwest Medicine.

National Hospital Record.

Annals of Gynecology and Pediatry.
American Medical Compend.

Modern Eclecticism.

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Since last month I have found the following three more. I again ask readers to aid me in keeping the profession posted as to the antikamnia journals, both by helping to make this list complete, if it is not already complete, and also to note any that discontinue the antikamnia adv. After all the exposures, isn't it a shame that the antikamnia list is so large? Here are the three just discovered:

Journal of Nervous and Mental Disease, Dr. Smith Ely Jelliffe (ex-editor of The Medical News), editor and publisher. American Journal of Obstetrics and Diseases of Women and Children.

Cleveland Medical and Surgical Reporter.

Rubber!

Ferdinand E. Borges, promoter of the Utero Rubber Plantation Company, which was prominent in some of the magazines not long ago, has been found guilty in Boston of conspiracy on one count and larceny on seventy-three.-Printers' Ink.

Query: Was any of this rubber stock bought by doctors? If so, wouldn't they like to have their money back? The best way is to not put money into such

schemes.

ORIGINAL COMMUNICATIONS

Short articles of practical help to the profession are solicited for this department.

Articles accepted must be contributed to this journal only. The editors are not responsible for views expressed by contributors. Copy must be received on or before the twelfth of the month, for publication in the issue for the next month. We decline responsibility for the safety of unused manuscript. It can usually be returned if request and postage for return are received with manuscript; but we cannot agree to always do so. Certainly it is excellent discipline for an author to feel that he must say all he has to say in the fewest possible words, or his reader is sure to skip them; and in the plainest possible words, or his reader will certainly misunderstand them. Generally, also, a downright fact may be told in a plain way; and we want downright facts at present more than anything else.-RUSKIN,

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Editor MEDICAL WORLD:-Since the publication of my brief article on whooping cough, page 260, I have been called on to answer so many letters of inquiry that it seems something more should be added. All ask for the address of this firm selling the ozonized syrup of tolu; and one, with a very sick baby, scolded quite sharply because I did not tell this and all about how I used the peroxid. Well, I supposed that doctors could be relied on to see short distances into a mill stone; but I am very willing to make allowance for and sympathize with the parent of a very sick child. It seems, too, that pertussis is prevailing now to a far greater extent than I dreamed of, and this is the time to put to a test something which in all sincerity appears of real value.

I've had no fixt rule, but have used about as follows:

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M. Sig. From 10 drops to 1 teaspoonful according to age. I give a dose every hour for two or three doses, then every two hours for six or eight, getting farther between doses as they improve.

Gentlemen, in my hands this has been highly satisfactory in quite a number of cases. Won't you try it?

The firm of Buchanan & Co., manufacturing chemists, New York, N. Y., some twelve or fifteen years ago advertised their ozonized preparations very extensivly. I tried a number of them but found good in only one. For several years I have not even seen their adv. I am also unable to give their street and number. DAVIS R. EMMONS.

North Lewisburg, Ohio.

Editor MEDICAL WORLD:-Having had quite a number of cases of whooping-cough to treat this spring, some of them very severe, especially in babies less than a year old, and having had excellent success with the use of fluidextract of castanea, I wish to suggest its use in proper dosage in young children with the above disease. I have used it in quite a

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Horse Nettle in Epilepsy.

Editor MEDICAL WORLD:- I have been interested in your reply to Dr. F. L. Gage, of Delaware, Ohio, regarding solanum carolinense. I have used many pounds of the fluidextract made by Parke, Davis & Co., in the treatment of epilepsy, both acute and chronic, and have received more good results from its use than from any other line of treatment. Now, I do not wish to be understood that I claim that horse nettle will cure all cases of epilepsy; but it will certainly surprise many physicians who have passed it over as being of no benefit in this dreaded disease, providing they take it up and give it until the physiological action is obtained. Many good drugs receive a poor reputation simply because the physicians do not give them in sufficient doses to obtain the physiological effect. I have had under treatment a man 36 years old who has had epilepsy for 20 years, and he was in such a condition that he was twice committed to the insane asylum. After spending one and two years in the asylum he was discharged, but he soon became as bad as ever. Under my treatment he has had two very slight attacks in a year. He now is able to work on his farm, and he said to me he felt he was going to get entirely well. Now, I began the treatment of this man by giving a half teaspoonful of fluidextract every three hours, and I increased it until he was taking four teaspoonfuls at a dose.

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As he improved I reduced the number of doses; he now is taking two doses a day-one night and morning. I have now under treatment two boys, aged 4 years and 9 years. These children were having seven or eight attacks a week. The oldest boy is now taking twenty drops four times a day, and the little one is taking ten drops. oldest boy has not had an attack in eight months, and the little one has had one very slight attack in four months. I had a very severe case to treat and I could not get the physiological effect in this case at all. I kept increasing the dose until he was taking six teaspoonfuls at a dose, and when he reacht this amount I found I received the physiological action to perfection and he made a good recovery and has not had an attack in two years. A number of our physicians

who saw this case were horrified to think I would give six teaspoonfuls of a fluidextract.

You will want to know what I call the physiological action of this drug? I would advise the physician using this drug to begin with the small dose and give it in mild cases until his patient has a feeling of drowsiness after each dose. In chronic cases that are considered bad, he should push the drug until it produces symptoms of vertigo after each dose, and then stop and hold his case at this point, then begin to gradually reduce the dose until he is taking only a few drops. It will pay any physician to study this drug, not only in the treatment of epilepsy but in various nervous diseases. Physicians cannot always be guided by the dose that they find laid down in the text-books or on the bottles from the manufacturer; but he must study his case and prescribe for the condition of his patient at the time he sees him; and having selected the drug he is going to use, give it until the physiological action of the drug is produced. Each case the doctor sees is a case by itself; it has its own problem to be solved, and it requires its own remedy. We find that Nature does not exactly adopt the same means of repair in any two cases. It is sur

prising the amount that we can learn about a drug that we thought we knew all about, if we will give it careful study. Palatka, Fla.

A. M. STEEN.

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M. Sig. Apply three or four times a day. This will certainly cure it, but I never use it now for the reason that I have found a never-failing remedy that cures it quicker and is perfectly harmless. It is a specific; and when I say specific I mean just what I say. The remedy is simply sulfate of quinin. Why it does it, and how it does it, I do not know; but I know it does it.

Just three days ago a man came to my office with the worst case of rhus poisoning I ever saw. It was all over his neck, breast, ears, face and eyes; also on his hands. His eyes were so swollen he could open them but little. He said: "Doctor, I am in a bad fix; can you cure me?" "I think I can," I replied. So I took a six-ounce bottle and put about one-fourth of an ounce bottle of quinin in it, filled it with water, shook it well and applied it thoroly. I then wrote a prescription for him, as he needed some other medicins for other troubles, and told him to go to the drug store, get his prescription filled and return. He was not gone thirty

minutes, but I could see he was much better when he returned. That was about 10 a.m. I told him if he wasn't much better by late that evening to come back. He did not return. I saw him this morning and he told me he never had medicin to act so much like magic in his life. Said he was practically well by night. Now, doctors, try it. It is a specific just as sure as I am writing.

How I came to use it: One day in company with Dr. Strange of this town, we were talking about rhus poisoning, and I told him that the first prescription given above was my remedy. He told me quinin was his, and said he had tried it in a number of cases and that it never failed to cure, and cured quickly. He said one time a man who had been poisoned with it came to his (Strange's) brother, who is also a physician, for treatment. His brother did not have what he wanted to give him, and to make the patient think he was doing something for him he prepared a solution of quinin and gave it to him and told him to apply it thoroly, and if he was not much better by the next morning to come back and he would have the other remedy. He never came; but in a few days he sent back for some more medicin just like that given him, that another person was poisoned, and it cured him so quickly he wanted the same kind for him. The doctor sent it and it cured the patient at once. Since that time he has treated many cases, used nothing else, and every case was cured quickly. The doctor said he has never thought of using anything else since, and it had never failed to cure. I said to myself, "I'll try it, but I doubt it curing every case.' Since then I have used nothing else, and it cures so quickly you would doubt it if I were to tell you. I have always been careful not to rush into print with a remedy and extol it unless I knew from actual experience what it will do. I tell you this is a specific for rhus poisoning. Try it, and you will never use anything else. I make this request of the WORLD family: Try it, and report. If you ever meet a case it fails to cure, I want to know it. Be sure your diagnosis is right. Magazine, Ark. T. J. DANIEL, M.D.

Sciatica.

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Editor MEDICAL WORLD:-On page 232, June WORLD, J. H. T., of Wyoming, Del., calls for a remedy for sciatica. I have found the following very efficient : Clear the bowels with calomel and soda and a saline, paint the loins thoroly with tincture of iodin along the course of the nerve, continue till it can be borne no longer, and after the surface has healed apply again. Keep the bowels activ, and when the pain is troublesome at night take Dover's powder enuf to give relief. Have cured myself and many others with this treatment. Charleston, Ill.

L. L. SILVERTHORN.

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