ing and dispensing lime water is offered by the Appert Glass Company, of 275 Broadway, New York, whose advertisement will be found in this issue. The faucet is placed at such a bight in a glass container that it enables the dispenser to draw off the clear liquid. This is something which every pharmacist can use to advantage, and as it is offered at a moderate price, we have no doubt that many of our friends will avail themselves of the opportunity.

The soaps, perfume and toilet articles of Solon Palmer, of New York, are admittedly the most successful articles in meeting American requirements. Solon Palmer's principle in confining his sales strictly to retail druggists has developed the loyalty of that trade and made it an active distributer of the goods. The goods are sold in all parts of the United States, and have now reached portions of South America and the far East, as shown by the establishment of agencies in Argentine and in the Straits Settlements.

Druggists should exercise great care when purchasing preparations of a similar name to Bromo-Seltzer, for should a decree be obtained by the Emerson Drug Company, manufacturers of Bromo-Seltzer, against the manufacturers of any preparation similar in name, they will be amenable to the law for having in stock or offering for sale such articles; further, they should be most careful when accepting stock in co-operative companies offering stock to the druggists in consideration of their purchasing a quantity order to see that the stock is full paid, for they are, according to law, liable to an assessment ou their stock should judgment be obtained against such companies, and they have not sufficient assets to satisfy same.

German vs. American Commercial Agents. United States Consul General Guenther of Frankfort, Germany, says in a recent report that: "The majority of United States manufacturers who are attempting to build up an export trade rely too much upon correspondence and the sending of catalogues, and these not always in the language of the country to which they are sent. In very rare cases agents are sent out, and most of these are not conversant with the foreign language required, and are usually too much pressed for time, and consequently do not study foreign conditions as carefully as they should. They labor under the mistaken idea that it is their mission to educate the whole world to adopt the English language and American customs, patterns, &c. The German agent does the reverse. He, as a general rule, is a linguist; he adapts himself to the conditions he finds where he wants to sell; he is in no hurry, but in a methodical manner goes to work and carefully studies every detail and does not depart until he is satisfied that he has acquired as full knowledge of trade conditions as is possible."

The Norwich Pharmacal Company's Fire.

On May 26 four out of nine buildings which constitute the manufacturing plant of the Norwich Pharmacal Company, at Norwich, N. Y., were destroyed by fire. Fortunately, their new building, containing 24,000 feet of floor space, in which was stored the bulk of their manufactured products, escaped unharmed. This will enable them to take care of their trade quite satisfactorily so far as their line of regular pharmaceutical and specialty preparations go, and they expect to be in a position to make up all special formulas that may come in after a week or so.

Druggists who wish any special formulas to be put up will find that they can get prompt and very efficient service from this firm. One result of the fire will be the early installation of the latest improved machinery on a very large scale. This business has grown steadily and rapidly, so rapidly, in fact, that the firm have never found the opportunity to shut down their factory to rebuild, but have simply continued to add one building after another as opportunity offered. Now that the fire has cleared the ground the company expect to erect a very large building fully equipped with the latest improved appliances for the preparation of pharmaceuticals, in addition to their own specialties.

The daily press of May 15 chronicled another victory for Chas. H. Fletcher in his fight against counterfeiters and substituters of that well-known preparation, Castoria, and his many friends in the trade who must appreciate his loyalty to trem will congratulate him on his success. Since "long befo' the wah" The Centaur Company, of whom Chas. H. Fletcher is president, and who have always paid the war taxes, the trade has found Fletcher's Castoria not alone a good seller, but a profitable one.

The newspapers' report of the case is as follows: St. Louis, Mo., May 14. "In the case of The Centaur Company of New York City, against The Palestine Drug Company and John Bick of this city, in the United States Circuit Court, an injunction was issued this morning, by Judge Adams, restraining the defendant's company from selling Castoria in a wrapper or label heretofore used by them and which is declared to be an imitation of The Centaur Company's wrapper. The enjoined label is similar to that of The Centaur Company, except where the signature of Chas. H. Fletcher appears on the genuine, the defendant has inserted that of Alph Arthur,' who is said to be a fictitious person."

PHILADELPHIA.

ISSUED SEMI-MONTHLY BY

THE AMERICAN DRUGGIST AND PHARMACEUTICAL RECORD is issued on the second and fourth Mondays of each month. Changes of advertisements should be received ten days in advance of the date of publication. Remittances should be made by New York exchange, post office or express money order or registered mail. If checks on local banks are used 10 cents should be added to cover cost of collection. The publishers are not responsible for money sent by unregistered mail, nor for any money paid except to duly authorized agents. All communications should be addressed and all remittances made payable to American Druggist Publishing Co., 62-68 West Broadway, New York.

If it is possible to find one ray of THE GENERAL SLOCUM comfort in the black tragedy of the “General Slocum," it is in the heroic conduct of the nurses and ward helpers on North Brother Island, who, at the risk of their own lives, saved those of many women and children. One woman helper, Mary McCann, is credited with four separate rescues by hard swimming, and Assistant Nurse O'Donnell saved eight people, besides bringing seven bodies to shore. Dr. Watson, the physician in charge, led this rescuing party, standing in the water and cheering them on.

BORAX INDICTED.

CHICAGO

After a year's experimental work, Dr. Harvey W. Wiley, Chief of the Bureau of Chemistry of the Department of Agriculture, has announced his conviction as a result of the experiments in question that the use of borax in food as a preservative is open to serious objection. The conclusions drawn by Dr. Wiley from his experiments are presented at some length in another column, and whether they are to be considered as final or not they undoubtedly merit very careful consideration as the experiments were conducted in a thoroughly scientific manner on human beings. One use of borax, and probably its largest use as a preservative, is specifically exempt from condemnation-namely, its application on the outside of meats where that portion of the meat is expected to be removed before cooking.

THE CONFERENCE OF THE BOARDS.

We are pleased to learn through Mr. Reimann, of Buffalo, chairman of the committee of the American Pharmaceutical Association appointed for the purpose of bringing about a conference of representatives from the various State Boards of Pharmacy, that the proposition has met with almost universal favor, and that the prospects now are that over a hundred delegates will be in attendance on the conference when it is called to order at Kansas City during the first week of September. The excellent work which has been done by the National Confederation of Medical Licensing and Examining Boards during the past few years is surely an indication that similar desirable results may be looked for through such an association of men charged with the examination and licensing of pharmacists. The work of organizing the conference is in excellent hands, and we urge all our readers who are connected with boards of pharmacy to make an effort to attend this conference and participate in its proceedings, the results of which cannot but be favorable to the best interests of pharmacy.

DATES CLASH HERE.

It is unfortunate, in some respects, that the date of the annual meeting of the American Pharmaceutical Association should conflict with that of the general annual meeting of the Society of Chemical Industry, which for the first time in the history of the society is to be held in the United States. The meeting occurs in New York during the second week of September, and will be attended by a distinguished gathering of chemists, including Sir William Ramsey, the president of the society, whose fame is universal through his discovery of the new elements, argon and helium, and his work on the radioactive substances. The New York Section of the society have prepared to give the visitors a strenuous time, the programme of entertainment including visits to the principal industries in New York and vicinity, after which they will be taken in special cars to Philadelphia, Washington, Pittsburgh, St. Louis, Chicago, Buffalo, Niagara Falls and Boston, visiting the principal chemical works and industries in which chemists are interested en route. We suppose it is now too late to effect a change in the date of meeting of either association, but it is unfortunate that the dates should clash.

to members of incorporated pharmaceutical associations only, is again in the lime light. At the meeting of the Manhattan Pharmaceutical Association last Monday evening a former secretary of the board brought a storm of disapproval upon himself by proposing to make the requirements for voting uniform throughout the State by doing away with the association membership requirement in the Eastern section. While we have

seldom or never found ourselves in agreement with this exsecretary's views, we are bound to confess that, in this instance, we are in sympathy with him. The licensed pharmacists and druggists of the State are entitled to the right of voting for members of the Board of Pharmacy, because they are registered pharmacists and druggists, and not because they happen to be members of this or that association. In this respect the licensed pharmacists and druggists of the Middle and Western sections really have the advantage of those nearer the seaboard, and if the Pharmacy law is to be amended this matter of making the requirements for voting uniform throughout the State should receive first attention.

The American Medical Association Condemns Proprietary Remedies.

The

In our news columns we present an abstract of the proceedings of the Section on Materia Medica, Pharmacy and Therapeutics at the fifty-fifth annual convention of the American Medical Association, held at Atlantic City, June 6 to 10. principal topic of discussion seemed to be that of proprietary remedies and the relation of the practicing physician to this line of preparations. The report as published in our columns scarcely does justice to the spicy and entertaining character of the proceedings, if we may judge by statements made to us by persons in attendance at the meeting. One eminent disciple of ethics (as viewed from the manufacturer's standpoint) was told pointedly, so we have learned, that it was not his province to discuss ethics, as he was merely a patent-medicine vender. Unfortunately, our reporter has failed to incorporate this item in his report, and, since we give it on hearsay, we refrain from mentioning the names of the participants in the discussion, both of whom are well known in pharmaceutical circles.

However spicy the discussions may have been, the most interesting result of the meeting has been the very clearly defined impression left upon the minds of the manufacturers of proprietary remedies of the kind most generally used by physicians that the American Medical Association is radically and entirely opposed to the use of proprietary remedies and that the Journal of the American Medical Association will be expected to do all that it can to discourage the use of these remedies and to punish those proprietors who have the temerity to place their goods before the medical profession. It remains to be seen whether the publishers of the Journal will consider the wishes of the members of the association as expressed by the section of any weight. If the wishes of the members as expressed by a formal resolution are acceded to, we shall expect the Journal to exclude from its columns the advertisements of all those preparations which are proprietary in character and which form so large a proportion of the armamentarium of the average practitioner. We fear, however, that is too much to hope for, since the business management of the official organ will not be likely to attach as much weight to the wishes of the members of the association as it does to the full-page advertisements of manufacturers at a rate of some $1,100 or $1,200 per annum, and, until the proprietors themselves take the initiative and withdraw their patronage, we feel confident that there will be no material reduction in the number of proprietary remedies advertised in the columns of the Journal of the American Medical Association at the modest rates mentioned.

The American Pharmaceutical Association.

The selection of Kansas City as a meeting place for the American Pharmaceutical Association was made, it is understood, with a view to accommodating that large portion of the Eastern membership which would probably desire to visit the Exposition at St. Louis in conjunction with their trip to the A. Ph. A. It is to be hoped that our hospitable friends in Kansas City will take this fact into consideration and will not provide so liberal an entertainment for the visitors as to make it necessary for the members to prolong their stay over more than, say, four days. This amount of time would give ample opportunity for the serious work, which, after all, is the reason for the existence of the association, and for a few social events which will enable the members to become acquainted with each other. Every year the working contingent of the association has protested against being compelled to spend six days at a meeting in order to do three, or at most four, days' work, and it would be better policy, not only this year, but as a rule, to concentrate all the work in the first four days of the week and to devote the remainder of the week to such junketing as may appeal to the Committee on Entertainment. Hitherto, as has been said, the desires of the working contingent have been ignored, and in hopes of "holding the crowd" the entertainments have been sandwiched between the sessions. It is true, of course, that this arrangement is one that appeals to the men of leisure and means, but it is also one which practically debars from participation in some portion of each year's proceedings a not inconsiderable number of men who cannot afford to spend more than three or four days in attendance.

Relating to the Sale of Carbolic Acid.

In discussing the question of regulating the sale of carbolic acid in our issue of March 14 we stated that "the Board of Pharmacy is vested with the authority to regulate the sale of poisons whenever in their judgment such action may be deemed necessary for the protection of the public."

Notwithstanding the fact that the great danger to life which lies in the promiscuous sale of carbolic acid in concentrated form is well known to all druggists, the Board of Pharmacy has not seen fit to exercise the authority vested in them to prevent such sale. In Chicago an ordinance has been enacted prohibiting the sale of carbolic acid, except in dilute solution, save on the prescription of a physician. The operation of this law in Chicago has been decidedly satisfactory, and so far as we are informed no serious objection to the ordinance has been raised by the drug trade or by the public.

The Board of Pharmacy of the State of New York occupies what we believe to be an absolutely unique position, being the only body of pharmacists in the United States vested with legislative powers; for the authority to regulate the sale of poisons is a distinctively legislative power. With this authority is carried a corresponding degree of responsibility, and we warmly second the suggestion of our correspondent, Dr. R. Ogden Doremus, in urging the board to formulate and put into operation regulations absolutely restricting the public sale of carbolic acid to solutions so dilute as to reduce materially the danger from poison either by misadventure or with suicidal intent.

There are few, if any, uses to which carbolic acid is put by the laity for which a 5 per cent. solution is not available, and our Board of Pharmacy would do well to promulgate some such regulations regarding the sale of the diluted acid as are provided in the above ordinance.

THE STATUS OF PHARMACY.'

As Revealed by an Examination of Five Hundred Prescriptions.

BY WM. F. KAEMERER, Columbus, Ohio.

That the work connected with the business of the retail pharmacist to-day calls for far less skill and scientific knowledge than formerly, no one who is actively engaged in the business can fail to notice. Particularly noticeable is the large percentage of prescriptions calling for proprietary preparations, ready-made pills and tablets, and the small percentage of them, the dispensing of which call for true pharmaceutical skill.

This is true also of the business outside of the preparation department. The sale of patent or proprietary preparations is largely on the increase. We sell less of roots and herbs than formerly, and these, with few exceptions, the public demand in compressed packages. We are compelled more and more to add to our stock other lines than drugs and medicines. The public expect us to handle and to know a little of everything, or else be regarded as not quite up-to-date.

In order to bring out more clearly how far this is true, especially in the dispensing of physicians' prescriptions, I have carefully gone over the last 500 prescriptions filled at our store and arranged them into five classes: (1) Those calling for proprietary preparations, either as a whole or in part; (2) those calling for ready-made pills, tablets, capsules or suppositories; (3) those calling for a single article only, but not proprietary; (4) those calling for two or more simple articles, the dispensing of which called for nothing more than weighing or measuring; (5) those calling for other operations besides weighing and measuring.

Of the 500 prescriptions examined, 132, or about 26 per cent., called for proprietary preparations and came under the first class. One hundred and ten, or 22 per cent., called for proprietary preparations only, and required only to be transferred to another bottle and properly labeled. Forty, or 8 per cent., came under the second class, calling for ready-made pills, tablets, capsules or suppositories. Sixty-nine, or 15 per cent., came under the third class, calling for only a single nonproprietary article. These were mostly prescriptions calling for either tinctures, fluid extracts, solutions, elixirs or syrups. One hundred and sixty, or 32 per cent., called for two or more simple articles and came under the fourth class. Their dispensing called for nothing more than weighing or measuring; it made no difference how they were compounded as long as the different ingredients had been correctly weighed or measurd. hundred, or 20 per cent., came under the fifth class. Of these 39 were for powders, 20 for capsules, 6 for pills, two for konseals, 24 for ointments, 1 for suppositories, 5 for eye waters and 3 for emulsions.

One

Class V, powders and capsules, did not call for much more skill than those of Class IV. Besides weighing, their dispensing required that they be divided into equal parts and folded in papers or inclosed in capsules. A few of them contained active ingredients and required careful trituration. A great many of them called for only one or two articles. Konseals require no special skill; all that is necessary is a little practice.

The making of pills calls for real skill and is one of the tests of a man's ability as a pharmacist. It is well to note that only six times, or about once in a hundred, were we called upon to make pills, none of which were out of the ordinary.

Of the 24 prescriptions calling for ointments, only three required special care. One was for yellow oxide of mercury ointment, one for compound iodine ointment and one for belladonna ointment.

Suppositories.-I regard the making of suppositories as the supreme test of a pharmacist's skill in compounding. If he can turn out a good suppository, you can rest assured that he can take care of most anything else likely to turn up at the

Read at the twenty-sixth annual meeting of the Ohio State Pharmaceutical Association, Cincinnati, June 7, 1904.

prescription counter. Only once out of the 500 prescriptions were we called upon to prepare suppositories. Plasters. Not even once.

Five prescriptions called for eye waters. With these it was necessary to be exact and careful as regards cleanliness. They also had to be filtered. Two of them called for percentage solutions and one we were ordered to sterilize. Three times we were called upon to prepare an emulsion. Three prescriptions were written in the metric system.

In one prescription an overdose was prescribed. Under Class IV a few times potassium chlorate, tincture of iron and either water, syrup or glycerin were ordered in a mixture. A novice might add the tincture of iron directly to the potassium chlorate, but an experienced man-never.

There was one other prescription that was prescribed several times and might make trouble if not carefully prepared. It called for mercuric chloride, potassium iodide and compound syrup of sarsaparilla. It is very necessary here to make sure that the mercuric iodide formed is completely dissolved.

Under the first four classes, and including powders and capsules under the fifth class, we have a total of 460 prescriptions, or 92 per cent., the dispensing of which calls for no special skill in compounding. Almost any one possessed of a fair education, who is familiar with the stock and a little experienced in handling drugs, could have dispensed them as well as a college graduate, registered pharmacist or assistant pharmacist. The greatest difficulty he would experience would be to make out the poor handwriting of the physicians and to fix the price. Of course, he could not have dispensed them according to law.

I do not suppose that these 500 prescriptions differ very much from the same number taken from any other pharmacy. Perhaps some of you, if you would look over your prescription files, would find even a worse state of affairs. It certainly does not look very encouraging from a strictly pharmaceutical point of view.

We might ask over a hundred different questions about the condition of pharmacy as disclosed by these prescriptions and the various causes that have brought about this condition, but the only ones that need be considered are these: Does the present state of affairs meet with public approval and are the people satisfied? Do they get better service?

While I regard it as a loss that we are not called upon to practice more of true pharmacy, there is also a gain which every proprietor should take advantage of-namely: that with comparatively little help we are enabled to transact a large volume of business. The public gains by getting its supply of drugs and medicines at a more reasonable rate, and consequently consumes a proportionately larger quantity. From my own observations I know the latter part of this statement to be true, although it is quite contrary to the general belief held among pharmacists.

Why Certain Substances Liquefy on Mixing. Chloral and camphor, menthol and carbolic acid, and many other combinations liquefy on mixing. Why?

The experiment of liquefying snow or ice by mixing with salt throws some light on these phenomena. The melting point of every substance is lowered by the addition of another if the latter be soluble in the liquid form of the first, a law which we have practical experience in many pharmaceutical operations. For instance, the slow solidifying of carbonic acid suppositories and chloral suppositories and the liquefaction of carbolis acid or glacial acetic acid by the addition of traces of water. The freezing point of the solvent is depressed, the depression depending on the quantity of substance dissolved, a fact made use of in the cryoscopic method of Raoult for the determination of molecular weights. Chloral, camphor, menthol, thymol, carbolic acid, etc., have comparatively low melting points, and, as they are mutually soluble in each other, the addition of the one to the other, if in suitable proportions, soon yields a solution liquid at normal temperature. The statement in the Pharmacopoeia under “Camphor.”—“It forms a liquid when triturated with chloral hydrate, menthol, phenol, or thymol "-is only true if the quantities triturated be correct.-W. DUNCAN.

SUGGESTIONS FOR IMPROVING BUSINESS.'

BY J. E. KIDD.

One of the greatest benefits we have found in helping us in our business is to be friendly with the traveling men and give them a chance to tell what other druggists in other towns are doing. By this means we have been able to get ideas that in a great many instances have been very profitable to us. They are always a jolly, good natured set of people, ready and willing to talk, and freely give any information that they have in store that they believe will be of benefit to their customers. As an illustration we will mention one little instance that was told us by a drummer of a druggist in North Georgia, who offered a premium for the one growing the largest turnips, grown from seed bought at his store. This idea struck us as a good one, and we immediately put it in operation, and for the last four years offered $5 premium for the five largest turnips grown from our turnip seed between June and November 1. We believe that this one idea alone has caused us to sell from 100 to 150 pounds more turnip seed every year than we had sold previous to that time. Give the drummers a warm heart and a welcome hand and a chance to talk and you will very often find that they can tell you some things that will be new and profitable.

SOLICITING BUSINESS.

One of the suggestions that occurs to us as being a good one and one that we have partly tried, but owing to the great demand on my time, I was not able to push as thoroughly as I should have liked to, is to have a solicitor call at the homes and solicit business. This plan when we first put into operation we found very profitable. This soliciting plan can not only be practically used in your own town, but you can send your solicitor into other towns, where brother druggists are sleeping over their rights and privileges.

MECHANICAL WINDOW DISPLAYS.

We cannot refrain from again mentioning the great benefit that we believe that good attractive window displays have been to us, especially those that have had mechanical contrivances that would cause the people to stop and inspect the window. They do not always create a demand when first arranged, but sometimes you will find that even weeks have elapsed before you will derive any benefit from it. We are great believers in this mode of advertising, and certainly there is no place in the whole store where the druggist's ingenuity can be more thoroughly brought out before the public. Arrange the windows attractively, display one article at a time, and use something of local interest, or something that is before the public eye, and this plan very often causes your window to be noticed and talked about more than anything else. The old and novel Ferris wheel placed in your window, the carriage carrying some one of your own preparations, is something that seems always ready to attract and give a lot of advertising, and creates talk in your community.

Recognizing that nearly all druggists are in moderate circumstances, and in many instances half owned by the jobber, they are in a rut trying to build up, and they find it a very difficult thing to do. The druggist often finds his business run ning him instead of him running the business. In nearly every instance they are the brightest and best educated men in the community, and certainly no business men devote more time to their business than they do.

GOODS OF YOUR OWN MAKE.

One of the ways to get out of this rut-the one thing that we use and has been profitable, and one that we heartily recom mend to every druggist-is to put up your own preparations. We are now making about 25 preparations of our own. We push them, we sell them on absolute guarantee, and in every instance where we can get a local recommendation from parties who have used them, we immediately use that testimonial in our local paper, as well as on counter folders, calling attention to the merit of our preparations. We find that the little speech that we generally have ready for each preparation is the one

1 Read at the annual meeting of the Georgia Pharmaceutical Assoclation, May 17, 1904.

that sells most of the goods for us. We insist on our employees suggesting to our customers the different things, and not only be satisfied with just filling their order just as they ask for it. For instance, if a man should come in our store and ask for a bottle of paregoric, he is certain, unless we are very much rushed, not to leave the store without some one making the suggestion that Kidd's Rum and Quinine Hair Tonic is something that every family should have on their dresser, or ask if he does not need some soap, perfume, or something else besides the article he calls for. In other words, we are not satisfied with simply acting as a slot machine, but we try to educate our clerks so as to be good salesmen in the drug store in the same way as is done by other merchants in the dry goods or grocery business. We all know that it is a right difficult thing to go in a dry goods store and purchase just a collar without having some suggestion made by the clerk for some other article. Now, this one thing alone causes them to sell hundreds of dollars more every year than they would otherwise. Seeing this, we are putting it in practice in our own store and are well pleased with it.

COMMISSIONS TO CLERKS.

We have found that the idea, which is not original with us, however, to allow the clerks a commission on all sales made by them of our own preparations has been of much benefit to us. In less than one year we have sold over 3,000 boxes and bottles of our remedies at retail, and we expect in the next 12 months to increase this either 25 or 50 per cent.

THE COUPON SYSTEM.

We intend to use the coupon system, with a rebate with our own preparations. This, we believe, will be of benefit in increasing the demand for our articles. At all times remember to guarantee your products and declare that the money will be gladly returned if the article is not what it is represented to be, and if the article is returned be sure to refund the money without any question, as by this means alone you will be able to do some of the best advertising you possibly could. Make your own preparations, push them, stand by them, and you will be respected more for it; your bank account will increase on account of it, and you will soon find yourself in love with your business, rather than your business being a bore to you.

In all things in your business try to be the first and most progressive one in your town; try to lead and let others follow.

Kalodal.-Crédé (Apotheker Zeitung, 1904, page 162,) describes, under the name of kalodal, a new albuminous substance, which is so easily absorbed that it may be used both in the form of hypodermic injections and by rectum. This preparation is made from meat and contains 95 per cent. of easily assimiable proteids, together with a small proportion of mineral substances (phosphates, salts of iron and sodium chloride). Kalodal is a pale, brownish-yellow powder, soluble in water. Its solutions vary in color, according to their concentration, from yellow to light brown, and have no odor nor any appreciable taste. They are alkaline in reaction and may be sterilized without injuring the product. Solutions containing 10 or 12 per cent. are still fluid, but if these are rendered more concentrated a thick liquid is obtained and finally a gelatinous paste. As a solvent, either distilled water or a physiological salt solution may be used. Usually a solution of from 10 to 12 per cent. strength is employed, prepared with water at a temperature of from 40 to 60 degrees C. The solution takes some time to be completed; the product is filtered once or twice, and then sterilized at from 105 to 120 degrees C.

The Amount of Caffeine in Coffee.-According to M. J. Katz (Archiv der Pharmacie, 1904, page 42,) a cup of coffee containing about 150 Cc. and prepared with the coffee usually found in the market contains 0.10 grammes of caffeine if 50 grammes of roasted coffee be allowed for 1,000 Cc. of the infusion. This is a quantity which is by no means to be sneered at, and even if doses like 1.50 of caffeine daily may be given as a medicine, it must not be forgotten that in such cases it is a question of a few doses and cannot be compared to the drinking of several cups of coffee daily for a long period of time.