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degrees below the atmospheric tempera-
ture.t But ordinary water evaporates too
slowly, and
more volatile liquids are
chosen instead. Since Faraday's time we
owe all our successes to various applica-
tions of this principle. The great advan-
tage possessed by this principle, and in
which it chiefly differs from the others,
is that it admits of being applied in suc-
cessive stages. We begin with an easily
liquefiable gas, and utilize the liquid pro-
duced from the liquefaction of a gas lique-
fying at a lower temperature. This in
turn liquefies another, and our cold pro-
duction is only limited by the number of
gases and the difficulty of maintaining
them at the low temperatures at which
they liquefy. The temperature at which
a liquefied gas becomes reconverted into
vapor, or in other words its boiling point,
is an index of the degree of cold it is
capable of producing; for as long as any
liquid remains whilst being converted into
a gas, the temperature of that liquid never
rises above its boiling point. A glance
at the following table of boiling points
will show what temperature each liquid
will produce when evaporating under or-
dinary atmospheric conditions.

Table of Boiling Points of Liquefied Gases.
(At ordinary atmospheric pressure.)

Contrasts of Pictet's and Faraday's Work.

Faraday was the first to make use of
the great cold produced by the evapora-
tion of a liquefied gas, Pictet the first to
use such gases in succession. Faraday's
pressures did not exceed 60 atmospheres,
Pictet's exceeded 650, Cailletet's were
about 300. The latter cooled his com-
pressed gas principally by its own sud-
den expansion (third method). Such
enormous pressures as those employed
by Pictet and Cailletet required the use
of specially strong apparatus, and all sub-
sequent experimenters have endeavored
to work with greater cold and less pres-
sure. To experimenters subsequent to
Pictet and Cailletet belongs the credit of
devising apparatus suitable for storing
the liquefied gases. The surrounding air
is a fiery furnace to some of these
liquefied gases-its temperature being
150 to 200° C. above that at which they
boil. From this atmosphere, if it is in-
tended to preserve them as liquids, they
must be protected by interposing layers
of non-conducting substances, and the
best non-conductors are the liquids them-
selves. The inner receptacle must be
surrounded by three or four others, and
the following arrangement shows how the
inner vessel is kept sufficiently cold:
Air surrounding outer receptacle, about
15° C.

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2d liquid ethylene

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3d liquid oxygen or air

Nitric oxide

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These boiling points are the liquid temperatures during spontaneous evaporation; but if the rate of evaporation be increased artificially by removing the atmospheric pressure, a much lower temperature is registered. Hastening the evaporation of a liquid in this method produces the same effect as hastening the solution of a solid in the method of freezing mixtures.

It can now be easily understood how to make use of this method in successive stages. We begin, say, with a freezing mixture capable of reaching 50° C. This liquefies the three gases at the head of the list. We preferably omit chlorine from further experiment on account of its action on the metal and washers of machinery, and, by choosing sulphur dioxide and causing it to evaporate rapidly in an exhausted vessel, can produce a temperature of 65° C., which is sufficiently cold to liquefy carbon dioxide when that gas has been slightly compressed. With liquid carbon dioxide a temperature of 78° C. is shown on spontaneous evaporation, but in an exhausted vessel the temperature falls to - 110° C. This temperature liquefies nitrous oxide and ethylene, pressure being in all cases added when necessary. Liquid nitrous oxide mixed with carbon disulphide gives, on similar evaporation, a temperature of 140°; and liquid ethylene evaporating in vacuo produces a temperature of 160° C. to 170° C. With this and pressure, air, oxygen, and nitrogen can be liquefied; and, finally, by means of liquid oxygen or air, we can liquefy hydrogen.

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In 1755 Dr. Cullen succeeded in freezing water by its own evaporation.

-180 to -190

Even with this protection there is a good deal of loss by evaporation, but it is possible to store them in this way for a considerable time.

Although the results so far obtained are only of scientific interest, they possess enormous potential values, and commercial applications of them will certainly follow. Liquid air especially would find thousands of practical uses.

The third method will only be referred to for the purpose of including it with the others. It is not intended here to deal with the subject of cold-storage chambers for the conveyance of meat, fruit, etc., with which this method is principally connected. Reference has necessarily been made to it under Cailletet's process for liquefying gases, and in his hands it has contributed to some of those astonishing results described chiefly under the second method. It is very probable that it will be the means by which helium shall follow the fate of all other gases.

We can readily conceive that this brief record of successes gives but an inadequate idea of the actual amount of work that has been done in connection with this subject during the past 170 years. A record of the failures would certainly occupy a much larger space, and might prove no less instructive. But of the failures we hear not. We only know that to produce these results science must be ever restlessly probing in this direction and in that, and constantly utilizing past successes as stepping stones to future triumphs. Faraday's bent glass tubes suggested a stronger apparatus to Thirlorier, and Thirlorier's liquefied_carbonic gas proved a useful tool in Faraday's hands. Pictet and Cailletet in their turn owe much to Andrews for his discoveries in critical temperatures, the knowledge of which enabled them to avoid the causes which prevented Faraday's complete suc

cess.

THE SECRETION OF THE AL-
KALOIDS IN CINCHONA.*

BY J. P. LOTSIJ, PH.D.
Government Botanist, Java.
The Leaf.

Both in young and old leaves the cells of the epiderm do not contain any alkaloid; only in the case of certain sickly plants do the leaves sometimes contain a little in the epiderm. In fact, when young and colorless, no portion of the leaf possesses alkaloid. In the case of C. Ledgeriana always, and in the case of C. succirubra generally, there is found underneath the upper surface of the leaf immediately below the epiderm a layer consisting of large colorless cells; this constitutes the so-called hypoderm.

When young the hypoderm possesses no alkaloid; the latter, however, soon appears, and from that period the hypoderm is always remarkable for the great quantity of alkaloid it contains. Although often in old "Ledger" leaves the alkaloid is, taking the leaf as a whole, not found without some difficulty; it is nevertheless easily discovered in the hypoderm. The cells in the hypoderm in the neighborhood of the veins of the leaf appear to possess more alkaloid than those at a distance from the veins. In the case of young leaves still of a brownish color derived from the red sap of the cells, the mesophyll contains a considerable quantity of alkaloid. In fully-developed leaves of C. succirubra the alkaloid can easily be shown to be present in the mesophyll, however always in smaller quantities than is the case with young leaves. Here, again, it is sometimes noticed that in the neighborhood of the veins of the leaf the mesophyll contains more alkaloid than it does at a distance from the same. Leaves of the C. succirubra developed in the dark and, therefore, naturally of a white color, contain the alkaloid in the hypoderm and in the mesophyll, and also in other cells. It is not on this account asserted that the alkaloid was formed in the dark; it may have been drawn from the store already present in the bark. In the mesophyll of old "Ledger" leaves the alkaloid can sometimes be found and sometimes not, but even if it can be found it is a matter of difficulty.

The woody vessels of the thinnest veins possess no alkaloid; but the author of this paper has met with it twice in the mesophyll sheath. The transition cells in the thicker veins of the leaf, which are a modification of the sieve vessels, do not contain any alkaloid, and the woody vessels of the thicker, more developed veins contain no alkaloid. The sieve tubes and the conducting cells, whose chief function is the transport of albuminous substances, possess little alkaloid. Neither does the epiderm of these thicker veins contain any alkaloid. The external layers of the covering of fundamental parenchyma, consisting of the so-called collenchyma cells, contain alkaloid. The innermost portion of this covering consisting of the usual parenchyma cells, when it does not contain any oxalate of lime, contains the alkaloid. The author

Abstract of a report published in the British and Colonial Druggist.

has never found the oxalate and the alkaloid present in the same cell.

The epiderm and the hairs of the stalk of the leaf contain no alkaloid; the cells of the collenchyma and the parenchyma contain some; the fecula sheath none; the pericycle some. The external portion of the medullary rays, that is to say, the portion lodged between the different parts of the phloëm, contains alkaloid. The cambium, as a rule, contains none; sometimes, however, it is found to contain some. In the phloëm, the so-called phloëm parenchyma alone contains alkaloid; the sieve tubes and conducting vessels do not. The medullary rays of the xylem portion may contain alkaloid, but this is by no means always the case. The cylinder of fundamental parenchyma in the centre of the stalk of the leaf contains alkaloid when oxalate of lime is absent. The gum resin receptacles do not contain alkaloid.

The Scales of the Bud.

The external, that is to say, the secreting portion of the glands of the scales of the bud, contains no alkaloid; the internal, the inactive portion, however, does contain some. In the cells of the parenchyma of the scales of the bud we find a good deal of alkaloid; in the epiderm and the hairs it is not to be found; in the dead scales shed from the plant there is still found alkaloid.

The Stem.

The growing point of the stem contains no alkaloid. Soon, however, the cells change into fibro-vascular bundles, and as soon as this is the case all the cells at the growing point possess alkaloid with the exception of the incipient vascular bundles. The epiderm of the stem does not contain alkaloid. The cells of the primary bark contain much alkaloid, with the exception of the sheath and epiderm, which here contain none. In the pith the quantity of alkaloid rapidly diminishes with time, and when the pith is dead disappears altogether.

Tissue inside the fecula sheath-If we take a young branch just beginning to grow in a lateral direction, we find alkaloid in the pericycle. The primary medullary rays possess both in the phloëm and in the xylem alkaloid. The cambium contains none. The parenchyma, situated between the woody vascular bundles, contains a little, and that between the sieve tubes contains much alkaloid.

in the woody parenchyma even in the oldest layers of branches having a thickness of 1 dm. The cells of the medullary rays contain the most, those of the medullary plates less, and those of the woody parenchyma the least.

Secondary Bark.

are

If we examine the bark of a cinchona plant we have, firstly, a tract containing many sieve vessels; secondly, a tract containing few; thirdly, the primary bark without any. As the bark parenchyma contains alkaloid, and since the sieve vessels contain none, we have an explanation of the fact known for long to chemists, but never explained, that the alkaloid diminishes as we proceed from the outside inwards. The bark fibres which, however, in comparison with the sieve vessels occupy little space, are also destitute of alkaloid. Inquiring more particularly what portions of the secondary bark contain alkaloid it is seen that the portions derived from the cambium cells contain alkaloid, as also do those cells which continue at a later stage as the cells of the medullary rays and plates, and of the bark parenchyma; in these, moreover, the alkaloid increases to a remarkable extent; those, however, which changed into sieve vessels, conducting cells, or bark fibres lose their alkaloid very speedily. As the primary bark increases in thickness sundry changes take place; the subepidermal layer of cells containing alkaloid is changed into a cork-forming cambium, which does not contain any alkaloid. On the inside of this cambium there is a tissue containing chlorophyll, the phelloderm. Toward the outer side it forms cork cells, which also contain the alkaloid; however, these soon die, and then they lose it. Sometimes, though relatively speaking seldom, the cambium contains alkaloid. In the places where the stomata were situated in the young bark, a new organ of respiration is developed, the so-called lenticel, whose tissue is found to contain the alkaloid. In consequence of the formation of cork, parts of the bark are cut off, and being deprived of nourishment dry up. These dried-up parenchyma cells contain minute quantity of alkaloid.

The Root.

a

In this the root-cap contains no alkaloid, and the growing point of the root, in contradistinction to that of the stem, contains none either. The epidermis of the root also contains none; sometimes, however, when cutting a rootlet through a little is found in the outermost layer of cells, but closer inspection teaches that the epidermis is gone, and that the external layer here consists of the exodermis. The latter sometimes contains alkaloid close to the growing point, and sometimes at a distance from the same. comThe

The fecula sheath and the tissues around it. The fecula sheath contains no alkaloid; all other cells of the primary bark, with the exception of those containing gum resin or oxalic acid and of the epiderm, contain alkaloid.

The secondary tissues.-As a rule, the cambium after the growth has menced contains no alkaloid, but occasionally it is found there. The future cortical or wood cells, while yet undifferentiated, contain alkaloid. The fully-developed woody vessels contain no alkaloid and the fully-developed woody fibres very seldom contain any. The various cells of the medullary rays and the medullary plates whether they belong to the primary or the secondary medullary rays or not contain alkaloid as also do the woody cells of the parenchyma. The alkaloid is found in the medullary rays and

endodermis sometimes contains alkaloid, and sometimes it is in the layer immediately adjoining this, which latter condition appears to be the rule. Older roots are found to possess the alkaloid in the greatest portion of the cells in the primary bark, always excepting the exodermis. In the central cylinder the author has not succeeded in discovering alkaloid, not even in the outermost layers of the cells of the pericycle; whereas it was found to be present in that portion of the

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originates from the pericycle contains alkaloid, as also do the newly-formed cork cells. Sometimes, however, the cambium contains none, but the cork cells are found to contain some. In the secondary root bark we find the alkaloid localized in precisely the same manner as in the stem. The wood of the root contains alkaloid in the medullary rays and plates, and in the wood parenchyma.

The Flower.

In a very young and tender state the parts of the flower do not contain alkaloid. When a little older, however, a considerable quantity is round in the petals; as age increases it diminishes. Nevertheless, old petals contain more in proportion than old leaves. The epiderm of the calyx and corona contains no alkaloid. A considerable quantity, however, is found in the sub-epidermal layers, and a moderate amount in the parenchyma. Generally speaking, the external appears to contain more than the internal parenchyma. The stamens when young only possess alkaloid in the filament and in the so-called connective tissue, but at a later period it appears in the epidermis also. The pollen-forming tissue and the cells that nourish this are without alkaloid, as is also the pollen itself.

The parenchyma of the style contains alkaloid. In the embryo we find more of it in the external parenchyma than in the internal; the epidermis contains none. That part that bears the young seeds, the placenta, and the internal wall of the fruit do not contain any alkaloid from the beginning of their development. The ovules contain none, and the partition in the fruit contains very little. The stem of the flower and of the fruit contain alkaloid in the parenchyma, but not in the sieve vessels. The author has not been able to find it, however, either in the seed or in the embryo. The large quantities of albuminous matter present render it impossible to assert this with certainty; the macro-chemical analysis alone can decide this point. The admixture of certain small portions of the wall of the fruit with the seeds must be most carefully guarded against. The cotyledons, however, are found to contain alkaloid very soon after germination.

2.

General Results.

1. The alkaloid is not contained in the sieve vessels, but in the parenchyma. It is present in the green cells. 3. The alkaloid appears as a constituent of living parenchyma-cells or cells of a kindred nature.

4. Cells containing oxalate of lime contain no alkaloid.

5. Generally speaking (there are exceptions) we find in the case of young organic matter at the growing point the alkaloid dissolved in the cell sap, but in older organic matter, as in the secondary bark, we find it in an amorphous solid condition.

6. Sometimes the alkaloid is present in the form of the tannate; whether it occurs combined with other acids was not investigated.

7. Very active organic matter, such as cambium, at the farthest portion from the growing point contains no alkaloid as a rule; but close to the centre of activity it is found in considerable quantities.

8. In the neighborhood of the growing point of the stem much more is found to be present than in the neighborhood of the growing point of the root.

Standards for Tinctures.

At a recent meeting of the Midland Chemists' Assistants' Association at Birmingham, Eng., John Barclay, B. Sc., suggested the desirability of having exact standards for the tinctures of the British Pharmacopoeia. It was urged to be essential for the sake both of the pharmacist and of the public that guidance as to the requirements of the Pharmacopoeia should be as definite as possible, and that the margin of variation in the strength of tinctures, due to variability in the drugs used, should be reduced to a minimum. The accompanying table-the result of numerous experiments conducted by the author-was submitted.

Consumption of Soap in China.

(Concluded from page 10.)

The most popular come from Great Britain, and are made especially for this market. These soaps are put up both in bars and in tablets. The shape of the latter, and the addition of a little perfume, make them more attractive for toilet use. Twenty bars make a box of nominally 50 pounds weight. The tablets come in 28 and 56 pound boxes, the latter containing from one hundred and twenty to one hundred and forty tablets, according to the size. Three and four tablets are attached in one bar, to be separated by the retail dealer. This soap is put down in Shanghai at prices which suit the purchasing power of the Chinese.

Wholesale prices, both for English and Japanese goods, are quoted in the last market report as follows:

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The nominal weight of the bars is 24 pounds, and of the tablets 6 to 7 ounces, but the samples purchased weigh no more than 26 ounces to 2 pounds per bar, and 4 and 5 ounces for tablets. Much of this difference is doubtless due to natural shrinkage.

So far as I have been able to learn, there are no soap factories in China. Manufacture was begun at this port, but proved unsuccessful.

The trade returns for 1897 are not yet published. The imports of soap for 1896 at Shanghai were 86,963 piculs, valued at 484,631 haikwan taels, ог 11,595,067 pounds at $392,551.11. Of this amount, 3,293,600 pounds were toilet soaps, valued at $176,538.69.

The value of the total imports of soap for all China in 1896 was 553,052 haikwan taels, or $431,772.12. The quantity was not reported, but it will be seen by comparison of the total value with that of the Shanghai import, that very little was imported elsewhere.

reason

why American

The demand is constantly increasing. and the future growth of the trade is practically unlimited. There is no good manufacturers should not share in it. To do so, it is necessary that an article equal to that supplied by Great Britain should be furnished at a little lower price than British merchants quote. Chinese do not readily exchange a popular brand of any line of goods for another, though shown to be equally good, unless the inducement of a cheaper price is offered. The goods ought also to bear a Chinese as well as an English mark, and care should be taken in selecting this to please Chinese taste, and to avoid anything that will offend their superstitions.

One other suggestion is offered as important to the successful introduction of any American goods-they should be placed in the hands of firms managed by Americans.

In the keen competition for the control of this market, it is not to be expected that agents of other nationalities, having business connections in their own lands, will fail to throw their influence, whenever possible, in favor of the trade of their own countrymen.

Americans only can successfully push American goods.-From consular report of E. T. Williams, Shanghai.

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Queries and Answers.

We shall be glad, in this department, to respond to calls for information bearing on pharmacy or any of its allied topics, and cordially invite our friends to make use of this column.

The name and address of the inquirer must accompany the communication, not for publication, but to assure attention, as we make it a rule to pay no regard to anonymous correspondence.

Detection of Boracic Acid.-C. S.A mixture of borax and boracic acid is much used for the preservation of milk, and from recent occurrences it would seem of meat also. The qualitative tests for the presence of borax compounds are simple, easily applied, and positive in their results. Their presence in milk may be detected by evaporating to dryness not less than 10 Cc. of the suspected milk, incinerating, slightly verdifying with hydrochloric acid, placing in the capsule a slip of turmeric paper in such a manner as to be only partly wetted by the liquid, and evaporating to dryness at 100° C. If boron compounds are present the part of the turmeric paper which was immersed in the liquid will acquire a brownish red color. On moistening the paper with a drop of caustic soda a variety of colors will be produced-green and purple usually predominating. On acidulating with hydrochloric acid the red color is restored, and is again changed to green and blue by treatment with excess of alkali.

A portion of the residue may also be treated with a few drops of sulphuric acid, methyl (wood) alcohol added and ignited, when, if boron compounds be present the flame will have a pronounced greenish tinge.

The tests may be applied to meat by boiling the meat in water, evaporating the water to dryness, and treating the residue as above.

Floor Wax.-W. P. D. C.-The basis of most floor wax is a paraffin of low melting point, though this is sometimes modified by the addition of other ingredients. One of the best formulas is the first of these given below:

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Mix and dissolve the camphor by agitation.

To Liquefy Carbolic Acid.—A. M. D. writes, "Kindly inform me how to make carbolic acid solutions from the crystals." We should not advise the attempt to make dilute solutions of carbolic acid directly from the crystals. The better way is to first liquefy the acid by placing the bottles containing it in hot water and allowing them to remain there until the acid is completely melted. The addition to the acid of either five per cent of water or one per cent of glycerin will then prevent recrystallization. The liquefied acid may then be measured out for solutions of lower percentage. It is the custom with most pharmacists to regard the 95 per cent acid formed by the addition of five per cent of water to the crystals as true acid, and no allowance is made in calculating lower percentage solutions for the added water or glycerin as the case may be.

Ferric Oxalate for Photography.-C. A. M.-As a general rule potassium oxalate is used as a means of preparing the iron salt by double decomposition. The following directions, published in the London "Pharmaceutical Journal," will prove useful where that salt is not in stock. Finely powder 52 Gm. of ammonia iron alum, and place in a tall 1,000 Cc. measure; onto this pour 20 Cc. liq. ammoniae fort. and 10 Cc. water, stir well for five

minutes and then fill up with water and allow the precipitate to settle down. De/cant the supernatant liquid and again fill up with water and repeat the operation till the washing waters no longer give a precipitate with barium chloride. Then set the beaker aside for twelve hours till the precipitate has subsided sufficiently to allow enough of the clear water to be drawn off, so that no more than 75 Cc. of total bulk of precipitate and water be left; to this add 21.5 Gm. of pure oxalic acid, and stir well and in a few minutes a perfect solution will be obtained which should be filtered through a small filter paper, and enough distilled water washed through the filter to make the solution measure 100 Cc. in all. The result is a 20 per cent solution of ferric oxalate, which must be kept in the dark.

Cod Liver Oil With Hypophosphites. -S. A. E.-The following formula is that used in the Roosevelt Hospital in this city and the resulting emulsion has been found perfectly satisfactory.

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Let Proprietor and Retailer Come Together.

Editor American Druggist:

I received a few days ago an announcement from Messrs. A. G. Spalding & Bros., the well-known sporting goods house, that hereafter they intended to sell direct to the retail trade and save to the retailers the profits of the middleman, and it occurred to me, considering the present relations of the wholesaler, retailer and proprietors, that this move of A. G. Spalding & Bros. might be the means of rearranging the relations between the three branches of the drug trade.

I am a retail druggist of long standing, and speaking, as I must, from that standpoint, it seems to me that those who naturally should come closely together are the proprietor and the retailer; their interests are identical and they should join hands for mutual protection and its resulting advantages. I am sure such organization can be made by the proprietors as will be effective for our good and it will be supported by the retailers. So far as I can learn from the reports of the St. Louis meetings, the wholesaler ought to be well pleased with the proposition that the proprietors shall sell only to jobbers, no matter if some retailers buy more in a year than many jobbers do; but the jobbers are not satisfied with this, for they ask the proprietors to give them a still larger profit than they now have, by increasing the discount. In this way the jobber is guaranteed both his profit (and an increased one at that) and his customers. All that I can see for the retailer under this scheme is only the hope of a little profit, and in cities where competition is very keen, this little profit will be cut very small. In short, the wholesaler has everything to

gain by this scheme and the retailer is left in a very uncertain condition as to the help which he can get out of it.

It is for this reason that I advocate a union between the proprietor and retailer, for I am sure that by coming together they can come nearer to a solution of the cut-rate problem than has ever been done before through the intervention of the wholesaler. I propose to accomplish this in the following way:

1. The proprietors are to establish a uniform price on their goods with a rebate discount of 10 per cent on all orders amounting to $25 or more. Freight to be allowed. Cash to accompany orders and no orders to be accepted from those who do not maintain stipulated prices.

2. Any retailer advertising rebate articles at less than stipulated prices, or prices agreed upon by the local, State or national organization, shall be deprived of further supplies direct from proprietors, and the sale of such articles, or a newspaper or circular containing advertisement or photograph of a bulletin, placard or window announcement of such cut rates, shall be sufficient evidence for withholding supplies of proprietors.

Under this plan the majority of the retailers would be able to get their goods at the lowest price, which would enable them not only to compete with anyone, but to make a profit on sales, which would also prevent the advertising of cut prices. In this way, the retailer will be safe from the competition which is as ruinous to him as it is annoying and unprofitable to yourselves. There will also spring up a cordial sympathy between the manufacturer and the retailer, the final distributor of proprietary articles, and this will take the place of the 'present strained relations between the two.

OSCAR L. KALISH,
Kalish Pharmacy.,

New York City, Jan. 10, 1899.

A Word from Dewey's State. To the Editor:

Sir I enclose you check for subscription, for the current year, to your valuable journal. You are to be congratulated on the assistance you have rendered the retail druggists in the stand they have taken and are taking against the selfish manufacturers. Vermonters, up here in Dewey's State, are not Ayer-y, nor can they be easily Hood-winked.

One sarsaparilla manufacturer, whose name appears below, was not content to realize a handsome thing, by raising the price of his medicine because of the war tax, but he sent canvassers around selling almanacs. Yes, selling almanacs, rather taking orders for them, and patent medicine almanacs at that!

or

Here's a short billet-doux I sent them: J. C. Ayer Co. Gentlemen: A few days since I gave to your agent an order for 200 almanacs. It has been an annoyance to me ever since, for I could not see why I should contribute a couple of dollars to advertise for a firm that was patriotic enough to raise the price of their medicine not sufficient only to cover the cost of stamping, but to realize a handsome profit out of the war tax. "The Lord helps those that help themselves." You have certainly helped yourselves handsomely. Now you had better pray, and not ask the burdened retail druggists to -exert their every effort in your behalf. You will please countermand my order.

Yours, very un-Ayer-like,

CHAS. W. HUMPHREY.

Poultney, Vt., Nov. 9, 1898.

Advertising Ideas.

Under this heading we shall conduct a practical discussion of store methods and advertising for retail druggists. The Department Editor will be pleased to criticise advertisements, suggest improvements and answer all questions coming within the scope of this department, provided they are accompanied by the name and address of the writer.

CRITICISM AND COMMENT.

Prize Advertisement.

The "American Druggist" offers a prize of One Dollar, each issue, for the best retail druggist's advertisement. The prize this time is awarded to Mr. James C. Hakes, Jersey City, N. J.

An Effective Folder.

So many good ads were submitted for this issue that decision was rendered difficult. Mr. Hakes' folder was considered a trifle better than any of the others.

This four-page folder is about the size of a 6 envelope. Brown ink and an excellent quality of paper have been used. The circular is well planned and well executed, barring a little awkwardness of expression in one or two places. This is the kind of a circular that sells goods and should be suggestive to others who have special preparations to push. Mr. Hakes also sends some small strips advertising other specialties. It is difficult to pass judgment on them because I do not know how they are used. One or two of them contain no address, and one not even the name of the remedy it is intended to exploit. The slips are very nicely printed and are probably enclosed in packages of the remedy or used in connection with some form of display. If not they need revision. I must request that those sending in printed matter tell how it was used or distributed.

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whole paper so that you can see the general make-up of our leading paper, and also see how the ads are located. The one on page six is intended to reinforce the larger ad on page eight. H. W. REUSSWIG.

Somerville, N. Y.

These ads are fairly good. The chief fault of both is lack of proper display. The plan of using your regular space to direct attention to your larger ad in a special position is a good one, though the heading should have been bolder and more to the point.

The matter in the large ad is excellent, but I failed to find the ad when I first looked for it. Never take a space the shape of the one used in this in stance. A narrow space running across several columns is always an awkward one to handle, and is rendered especially difficult in this case by the make-up of the page. A special border would have helped to cut the ad out of the mass, but it is apparent that no choice was allowed in that regard. A good plan when going into a special edition is to play havoc with the geometrical lay-out planned by the printer. It is better to knock the symmetry out of his page than to risk having your ad eclipsed by its surroundings.

Good Holiday Advertising. Editor Business Hints:

I consider the AMERICAN DRUGGIST one of the best pharmaceutical journals. I think the columns devoted to advertising one of the best features of the paper, and derive good suggestions from them. As I have charge of all the advertising we do, I enclose a folder we had out during the holiday season, from which we derived great benefit. It was something unique and excited a great deal of comment. We believe in persistent advertising and also in striking window displays. I would like to submit this in your prize contest.

Philadelphia.

C. SHERWOOD CAMERON, Mgr. Campbell's Pharmacy.

The circular is entitled "Holiday Suggestions," and is a very excellent piece of work. It is a folder printed on tinted deckle edge paper, the lower fold extending beyond the upper far enough to permit the printing of the address on the exposed portion. The body matter is hidden until the upper fold is raised.

While the folder is neat and attractive, I believe that the material in it should have had more of a chance; that this is an instance where still greater expense would have been economy. The matter is set in nonpareil type, which is too small. Had pages been inserted and the deckle edge paper used as a cover there would have been more opportunity to properly display the matter, the excellence of which is illustrated by the following extract:

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